Med1 - mediator complex subunit 1 Gene

Rattus norvegicus

Also known as RGD1559552

Gene ID: 497991 | Gene type: protein coding

About Med1

Summary

Enables DNA binding activity; nuclear receptor binding activity; and transcription coregulator activity. Contributes to ubiquitin protein Ligase activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in chromatin and nucleus. Part of protein-DNA complex and ubiquitin Ligase complex. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Med1 Products(1)

mRNA	Protein	Name
NM_001134361.1	NP_001127833.1	mediator of RNA polymerase II transcription subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20702579	RGD
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	20702579	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	20378540	RGD
enables general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	10037764	RGD
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	10037764	RGD
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10037764	RGD
enables nuclear vitamin D receptor binding	IDA IDA: Inferred from direct assay	17786964	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	10037764	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10037764	RGD
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10037764	RGD
contributes to ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	12149480	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to thyroid hormone stimulus	IDA IDA: Inferred from direct assay	12034878	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10037764	RGD
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	12149480	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20702579	RGD
part of protein-DNA complex	IDA IDA: Inferred from direct assay	10037764	RGD
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12149480	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08184	MBD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08278	MED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18247	Med1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19616	Mbd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22462	Cwc15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24727	Med1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Med1	NCBI	NCBI:5469
Mus musculus	Med1	NCBI	NCBI:19014

Name
Email *

	Sorry, but the email address you supplied was invalid.