Med1 - mediator complex subunit 1 Gene

Mus musculus

Also known as PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; l11Jus15

Gene ID: 19014 | Gene type: protein coding

About Med1

Summary

Enables several functions, including promoter-specific chromatin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cellular response to hepatocyte growth factor stimulus; and regulation of signal transduction. Located in nucleus. Part of mediator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Used to study congestive heart failure and dilated cardiomyopathy. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Med1 Products(5)

mRNA	Protein	Name
NM_001080118.1	NP_001073587.1	mediator of RNA polymerase II transcription subunit 1 isoform 3
NM_001361950.1	NP_001348879.1	mediator of RNA polymerase II transcription subunit 1 isoform 4
NM_001361951.1	NP_001348880.1	mediator of RNA polymerase II transcription subunit 1 isoform 5
NM_013634.2	NP_038662.2	mediator of RNA polymerase II transcription subunit 1 isoform 1
NM_134027.2	NP_598788.2	mediator of RNA polymerase II transcription subunit 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15681609	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11724781	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	12446761	MGI
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	9325263	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22323595	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9325263	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15340084	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9325263	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	16723356	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of G0 to G1 transition	IMP IMP: Inferred from mutant phenotype	17438330	MGI
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	11724781	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10747854	MGI
acts upstream of or within animal organ regeneration	IMP IMP: Inferred from mutant phenotype	17438330	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	10882104	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	14500757	MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus	IMP IMP: Inferred from mutant phenotype	17438330	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	14500757	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	14500757	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	14500757	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	14500757	MGI
acts upstream of or within enucleate erythrocyte development	IMP IMP: Inferred from mutant phenotype	21098667	MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation	IMP IMP: Inferred from mutant phenotype	15647257	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	17132730	MGI
involved in erythrocyte development	IMP IMP: Inferred from mutant phenotype	11724781	MGI
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	12037571	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10882104	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	16324150	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	14500757	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	15647257	MGI
involved in lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	11724781	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	14500757	MGI
involved in mRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16723356	MGI
acts upstream of or within mammary gland branching involved in pregnancy	IMP IMP: Inferred from mutant phenotype	15647257	MGI
acts upstream of or within mammary gland branching involved in thelarche	IMP IMP: Inferred from mutant phenotype	15647257	MGI
acts upstream of or within mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15843544	MGI
involved in megakaryocyte development	IMP IMP: Inferred from mutant phenotype	11724781	MGI
acts upstream of or within monocyte differentiation	IMP IMP: Inferred from mutant phenotype	16324150	MGI
acts upstream of or within multicellular organism development	IMP IMP: Inferred from mutant phenotype	10882104	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16723356	MGI
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16723356	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16723356	MGI
acts upstream of or within peroxisome proliferator activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15150259	MGI
acts upstream of or within positive regulation of G0 to G1 transition	IMP IMP: Inferred from mutant phenotype	17438330	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10882104	MGI
acts upstream of or within positive regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	17438330	MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20351249	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11724781	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17827210	MGI
acts upstream of or within positive regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18339625	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	16828057	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9325263	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10882104	MGI
acts upstream of or within regulation of vitamin D receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16324150	MGI
involved in retinal pigment epithelium development	IMP IMP: Inferred from mutant phenotype	11724781	MGI
acts upstream of or within thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	10882104	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	11724781	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of mediator complex	IDA IDA: Inferred from direct assay	12093747	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15150259	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 1

PPAR-binding protein	Ppar binding protein
TR-interacting protein 2	peroxisome proliferator-activated receptor-binding protein
thyroid hormone receptor-associated protein complex 220 kDa component	thyroid receptor-interacting protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08278	MED1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18247	Med1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24727	Med1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Med1	NCBI	NCBI:5469

Name
Email *

	Sorry, but the email address you supplied was invalid.