MBP - myelin basic protein Gene

Homo sapiens

Gene ID: 4155 | Gene type: protein coding

About MBP

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:76,978,833-77,133,708 (from NCBI)

This gene has 49 transcripts (splice variants) and 285 orthologues. Biased expression in brain (RPKM 287.3) and thyroid (RPKM 8.9).

Summary

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

MBP Products(6)

mRNA	Protein	Name
NM_001025081.2	NP_001020252.1	myelin basic protein isoform 1
NM_001025090.2	NP_001020261.1	myelin basic protein isoform 3
NM_001025092.2	NP_001020263.1	myelin basic protein isoform 4
NM_001025100.2	NP_001020271.1	Golli-MBP isoform 2
NM_001025101.2	NP_001020272.1	Golli-MBP isoform 1
NM_002385.3	NP_002376.1	myelin basic protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IPI IPI: Inferred from physical interaction	19855925	GOA
enables lipid binding	EXP EXP: Inferred from Experiment	18326633	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17064692	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	22524708	GOA
involved in maintenance of blood-brain barrier	IDA IDA: Inferred from direct assay	22524708	GOA
involved in negative regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	22524708	GOA
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	22524708	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	22524708	GOA
involved in positive regulation of metalloendopeptidase activity	IDA IDA: Inferred from direct assay	22524708	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in myelin sheath	IDA IDA: Inferred from direct assay	19855925	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19855925	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MBP Protein Structure

Myelin_MBP

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

myelin basic protein

Golli-MBP

myelin A1 protein

MBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MBP	P02686	IDE	Homo sapiens	P14735	Anti Tag CoIP	33961781
Intra	MBP	P02686	CTDSP1	Homo sapiens	Q9GZU7	Y2H Array	31515488
Intra	MBP	P02686	CTDSP1	Homo sapiens	Q9GZU7	Anti Tag CoIP	33961781
Intra	MBP	P02686	CTDSP1	Homo sapiens	Q9GZU7	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

MBP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83526	Myelin Basic Protein Antibody (YA3271)	WB	Human, Rat
HY-P85921	Myelin Basic Protein Antibody (YA5613)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86014	Myelin Basic Protein Antibody (YA5706)	IHC-P, ELISA	Human, Mouse, Rat
HY-P86918	Myelin Basic Protein Antibody(YA6611)	WB, IHC-P, IHC-F, IF-Tissue, mIHC	Human, Mouse, Rat, Monkey, Pig

Related Diseases

Diseases

Alias

Secondary Progressive Multiple Sclerosis

Secondary-Progressive Ms	Spms
Multiple Sclerosis, Chronic Progressive	Chronic Progressive Multiple Sclerosis
Multiple Sclerosis, Secondary Progressive

Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder

Neuromyelitis Optica

Devic Disease	Devic Syndrome
Neuromyelitis Optica Spectrum Disorder	Devic'S Disease
Devic'S Syndrome	Devic'S Neuromyelitis Optica
Nmo	Nmo Spectrum Disorder
Neuromyelitis Optica Spectrum Disorders	Devic Neuromyelitis Optica
Optic-Spinal Ms	Opticospinal Ms
Nmosd	Opticospinal Multiple Sclerosis
Devic	Ophthalmoneuromyelitis
Optic Neuromyelitis	Optic Neuroencephalomyelopathy
Nmo - [Neuromyelitis Optica]	Optic Neuritis With Demyelination

Acute Disseminated Encephalomyelitis

Acute Disseminated Encephalitis	Adem
Ade	Encephalomyelitis Acute Disseminated
Encephalomyelitis, Acute Disseminated	Adem - [Acute Disseminated Encephalomyelitis]

Optic Neuritis

Inflammatory Optic Neuropathy

Guillain-Barre Syndrome

Guillain-Barré Syndrome	Acute Inflammatory Polyneuropathy
Gbs	Acute Inflammatory Demyelinating Polyneuropathy
Acute Inflammatory Demyelinating Polyradiculoneuropathy	Acute Infective Polyneuritis
Acute Inflammatory Demyelinating Polyradiculopathy	Acute Postinfectious Polyneuropathy
Infectious Neuronitis	Post-Infectious Polyneuritis
Postinfectious Polyneuritis	Acute Autoimmune Peripheral Neuropathy
Acute Immune-Mediated Polyneuropathy	Acute Inflammatory Neuropathy
Guillain-Barré-Strohl Syndrome	Landry'S Ascending Paralysis
Landry-Guillain-Barre-Strohl Syndrome	Post-Infective Polyneuritis
Acute Infectious Polyneuritis	Fisher Syndrome
Landry-Guillain-Barre Syndrome	Guillain-Barre-Strohl Syndrome
Variant Of Guillain-Barre Syndrome	Variant Of Gbs
Aidp	Acute Idiopathic Demyelinating Polyneuropathy
Gbs, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form	Guillain-Barre Syndrome, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form
Miller Fisher Syndrome

Chromosome 18q Deletion Syndrome

18q- Syndrome	Monosomy 18q
Deletion Of Long Arm Of Chromosome 18	Chromosome 18q- Syndrome
Deletion 18q	18q Deletion Syndrome
Distal 18q Deletion Syndrome	Chromosome 18 Long Arm Deletion Syndrome
Chromosome 18q Monosomy	Del Syndrome
Chromosome 18 Deletion Syndrome

Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms	Relapsing Remitting Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting	Rrms
Multiple Sclerosis Relapsing-Remitting

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Pelizaeus-Merzbacher Disease

PMD	HLD1
Pelizaeus-Merzbacher Brain Sclerosis	Leukodystrophy, Hypomyelinating, 1
Diffuse Familial Brain Sclerosis	Pelizaeus Merzbacher Brain Sclerosis
Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type	Cockayne-Pelizaeus-Merzbacher Disease
Hypomyelinating Leukodystrophy 1	Leukodystrophy, Sudanophilic
Pelizaeus Merzbacher Disease	Hypomyelinating Leukodystrophy, 1
Sudanophilic Leukodystrophy	Pelizaeus-Merzbacher Disease, Connatal Form
Connatal Pmd	Pelizaeus-Merzbacher Disease Type Ii
Severe Pmd	Null Syndrome
Plp1 Null Syndrome	Pelizaeus-Merzbacher Disease, Null Syndrome
Brain Sclerosis Diffuse Familial	Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type
Leukodystrophy Hypomyelinating 1	Diffuse Cerebral Sclerosis Of Schilder

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Neuritis

Peripheral Neuritis

Central Pontine Myelinolysis

Myelinolysis, Central Pontine	Osmotic Demyelination Syndrome
Cpm	Myelinolysis Central Pontine
Central Pontine Myelinosis

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Chiari Malformation

Transverse Myelitis

Myelitis Transverse

Myelitis, Transverse

Polyradiculoneuropathy

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Chronic Inflammatory Demyelinating Polyneuropathy	Cidp
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Akinetic Mutism

Coma Vigilans

Myelitis

Spinal Cord Inflammation Nos	Radiculomyelitis Nos
Myeloradiculitis

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Subacute Sclerosing Panencephalitis

SSPE	Dawson Encephalitis
Immunosuppressive Measles Encephalitis	Subacute Sclerosing Leukoencephalitis
Panencephalitis, Subacute Sclerosing	Subacute Sclerosing Leukoencephalopathy
Van Bogaert'S Sclerosing Leukoencephalitis	Dawson Disease
Subacute Inclusion Body Encephalitis	Van Bogaert Disease
Van Bogaert Encephalitis	Measles Inclusion Body Encephalitis
Mibe - [Measles Inclusion Body Encephalitis]	Sspe - [Subacute Sclerosing Panencephalitis]
Van Bogaert Leukoencephalitis	Van Bogaert Sclerosing Leukoencephalitis
Dawson Inclusion Body Encephalitis	Van Bogaert Sclerosing Leukoencephalopathy
Bodechtel Guttman Disease	Diffuse Sclerosing Encephalitis

Krabbe Disease

Globoid Cell Leukodystrophy	Galactosylceramide Beta-Galactosidase Deficiency
Galc Deficiency	Galactocerebrosidase Deficiency
GLD	Globoid Cell Leukoencephalopathy
Diffuse Globoid Body Sclerosis	Gcl
Leukodystrophy, Globoid Cell	Krabbe'S Leukodystrophy
Krabbe Leukodystrophy	KRB
Beta Galactocerebrosidase Deficiency	Krabbe'S Disease
Galactosylceramidase Deficiency Disease	Galactosylceramide Lipidosis
Galactosylcerebrosidase Deficiency	Galactosylsphingosine Lipidosis
Psychosine Lipidosis	Galactosylceramidase Deficiency
Infantile Globoid Cell Leukodystrophy	Krabbe Brain Sclerosis

Myasthenia Gravis

MG	Acquired Myasthenia
Autoimmune Myasthenia Gravis	Erb-Goldflam Disease
Mg - [Myasthenia Gravis]	Myasthenia Gravis Nos
Myasthenia

Aging

Central Nervous System Disease

Cns Disorder	CNS
Cns Diseases	Central Nervous System Diseases

Viral Encephalitis

Epidemic Encephalitis	Encephalitis Viral
Encephalitis, Arbovirus	Arbovirus Encephalitis
Postviral Encephalitis Nos	Equine Encephalitis
Tick-Borne Encephalitis	Viral Encephalitis Transmitted By Tick
Mosquito-Borne Encephalitis	Acute Haemorrhagic Encephalitis
Acute Idiopathic Encephalitis	Chronic Viral Encephalitis
Endemic Encephalitis	Subacute Viral Encephalitis
Viral Haemorrhagic Encephalitis	Viral Nonepidemic Encephalitis
Nonepidemic Encephalitis

Dysgammaglobulinemia

Polyneuropathy

Polyneuropathies

Balo Concentric Sclerosis

Balo'S Concentric Sclerosis	Balo Disease
Diffuse Cerebral Sclerosis Of Schilder	Tumefactive Multiple Sclerosis
Concentric Demyelination	Balo'S Disease
Baló Concentric Sclerosis	Encephalitis Periaxialis Concentrica
Marburg Variant

Autoimmune Disease Of Peripheral Nervous System

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Encephalomalacia

Niemann-Pick Disease, Type A

Niemann-Pick Disease Type A	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency	Niemann-Pick Disease, Intermediate, Protracted Neurovisceral
Acid Sphingomyelinase Deficiency, Neurovisceral Type	Asmd, Neurovisceral Type
Infantile Neurovisceral Acid Sphingomyelinase Deficiency	Infantile Neurovisceral Asmd
Npd-A	Niemann-Pick Disease A
NPDA	Classical Niemann-Pick Disease
Niemann-Pick Disease Acute Neuronopathic Form	Niemann-Pick Disease Acute Neurovisceral Form
Niemann-Pick Disease Classical Infantile Form	Niemann-Pick Disease Intermediate Protracted Neurovisceral
Niemann-Pick Disease Neuronopathic Type	Niemann-Pick Disease Type I
Npa	Niemann-Pick Diseases

Neonatal Hypoxic And Ischemic Brain Injury

Perinatal Asphyxia	Hypoxic-Ischemic Encephalopathy
Perinatal Hypoxia	Hie
Hypoxic And Ischemic Brain Injury In The Newborn	Encephalopathy, Hypoxic Ischemic
Encephalopathies Hypoxic-Ischemic	Hypoxic Ischemic Encephalopathy
Hypoxic Ischaemic Brain Injury	Brain Hypoxia
Cerebral Hypoxia	Hypoxic Encephalopathy
Hypoxic Brain Damage	Hypoxic Brain Injury
Brainstem Hypoxia	Hypoxic Brainstem Damage

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Autoimmune Disease Of Central Nervous System

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Carotid Artery Occlusion

Occlusion And Stenosis Of Carotid Artery

Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius

Aqueductal Stenosis	Aqueductal Stenosis, X-Linked
Hsas	Hsas1
Hycx	Hydrocephalus, X-Linked
Xlas	X-Linked Hydrocephalus Syndrome

Vulvar Dystrophy

Dystrophy Of Vulva

Finger Agnosia

Acute Retrobulbar Neuritis

Retrobulbar Neuritis

Retrobulbar Optic Neuritis

Meningovascular Neurosyphilis

Periventricular Leukomalacia

Leukomalacia, Periventricular	Pvl
Leukomalacia Periventricular

Tropical Spastic Paraparesis

Tropical Spastic Paraplegia	Ham/Tsp
Htlv-Associated Myelopathy	Tropical Spastic Paralysis
Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis	Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis
Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis	Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis	Tsp
Paraparesis Tropical Spastic	Paraparesis, Tropical Spastic

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Neurilemmoma

Schwannoma	Benign Schwannoma
Neurilemoma	Peripheral Fibroblastoma
Psammomatous Schwannoma	Neurolemmoma
Schwannomas

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Autoimmune Optic Neuritis

Meningoencephalitis

Acquired Toxoplasmal Meningoencephalitis	Meningoencephalitis Due To Acquired Toxoplasmosis
Meningoencephalitis Due To Toxoplasmosis	Toxoplasma Meningoencephalitis

Internuclear Ophthalmoplegia

Ophthalmoplegia Internuclearis	Bielschowsky-Lutz-Cogan Syndrome
Ino - [Internuclear Ophthalmoplegia]	Lhermitte Syndrome
Mlf - [Medial Longitudinal Fasciculus] Syndrome	Internuclear Paralysis

Cranial Nerve Disease

Cranial Nerve Disorder	Disorder Of Cranial Nerve
Cranial Nerve Diseases

Vascular Dementia

Dementia, Vascular	Multi Infarct Dementia
Multifocal Dementia	Dementia Vascular
Vascular Dementia, Susceptibility To	Dementia, Multi-Infarct
Multi-Infarct Dementia

Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures	Postvaccinal Encephalomyelitis
Encephalomyelitis, Acute Disseminated

Progressive Relapsing Multiple Sclerosis

Prms	Progressive-Relapsing Ms
Multiple Sclerosis, Progressive Relapsing

Charcot-Marie-Tooth Disease And Deafness

Charcot-Marie-Tooth Disease Type 1e	CMT1E
Charcot-Marie-Tooth Disease Type 1	Hereditary Motor And Sensory Neuropathy Type 1
Charcot-Marie-Tooth Disease, Demyelinating, Type 1e	Charcot-Marie-Tooth Disease, Type I
Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant	Charcot-Marie-Tooth Disease, Type 1e
Charcot-Marie-Tooth Disease Demyelinating Type 1e	Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease
Cmt1	Charcot-Marie-Tooth Neuropathy Type 1
Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness	Charcot-Marie-Tooth Disease-Deafness
Charcot-Marie-Tooth Type 1	Hmsn1
Hereditary Motor And Sensory Neuropathy 1	Cmt 1e
Charcot Marie Tooth Disease Type 1e	Charcot-Marie-Tooth Disease-Deafness Syndrome
Charcot-Marie-Tooth Disease-Hearing Loss Syndrome	Charcot-Marie-Tooth Disease 1e
Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant	Charcot-Marie-Tooth Neuropathy Type 1e
Charcot-Marie-Tooth Disease, Type Ie	Hereditary Motor And Sensory Neuropathy Type I

Striatonigral Degeneration

Olivopontocerebellar Atrophy

Thomas Syndrome	Olivopontocerebellar Atrophies
Dejerine-Thomas Syndrome	Thomas' Syndrome
Wadia-Swami Syndrome	Opca
Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome	Spinocerebellar Ataxia Type 2

Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome	AIDS
Acquired Immune Deficiency	Acquired Immunodeficiency
Acquired Immunodeficiency Due To Protein Loss

Postinfectious Encephalitis

Postinfective Encephalitis

Secondary Encephalitis

Granulomatous Angiitis

Vasculitis, Central Nervous System

Chronic Salpingo-Oophoritis

Chronic Salpingitis And Oophoritis

Chronic Salpingitis/Oophoritis

Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy

Copper Deficiency Myelopathy

Swayback

Human Swayback

Cerebral Degeneration

Brain Degeneration

Degenerative Brain Disorder

Acute Hemorrhagic Leukoencephalitis

Ahl	Acute Haemorrhagic Leucoencephalitis Of Weston Hurst
Leukoencephalitis, Acute Hemorrhagic	Acute Hemorrhagic Encephalomyelitis
Acute Necrotizing Hemorrhagic Leukoencephalitis	Weston-Hurst Syndrome
Ahle	Acute Haemorrhagic Leucoencephalitis
Hurst Disease	Acute Haemorrhagic Leukoencephalitis, Postimmunization Or Postvaccinal
Postimmunization Or Postvaccinal Leukoencephalopathy

Arachnoiditis

Spinal Arachnoiditis	Adhesive Arachnoiditis
Chronic Arachnoiditis	Familial Spinal Arachnoiditis
Arachnitis	Arachnoid Inflammation

Canavan Disease

Aspartoacylase Deficiency	Aminoacylase 2 Deficiency
Spongy Degeneration Of Central Nervous System	Aspa Deficiency
Acy2 Deficiency	Canavan-Van Bogaert-Bertrand Disease
Mild Canavan Disease	Asp Deficiency
Spongy Degeneration Of The Central Nervous System	Severe Canavan Disease
Von Bogaert-Bertrand Disease	Canavan'S Disease
Spongy Degeneration Of The Brain	Juvenile Canavan Disease
Infantile Canavan Disease	Neonatal Canavan Disease
CAND	Disease, Canavan
Canavan Disease, Juvenile	Canavan Disease, Infantile
Canavan Disease, Neonatal

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Agraphia

Spinal Cord Disease

Spinal Cord Diseases	Myelopathy
Bone Marrow Diseases

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Bell'S Palsy

Bell Palsy	Facial Nerve Palsy
Facial Palsy	Facial Paralysis
Bell'S Palsy	Antoni'S Palsy
Facial Cranial Nerve Paralysis	Idiopathic Facial Palsy
Refrigeration Palsy	Facial Nerve Paralysis
Seventh Cranial Nerve Paralysis	Face Paralysis Nos

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Acute Necrotizing Encephalitis

Acute Necrotizing Encephalopathy	Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy
Ane	Acute Necrotizing Encephalopathy Type 1
Adane	Ane1
Autosomal Dominant Acute Necrotizing Encephalopathy	Iiae3
Susceptibility To Acute Necrotizing Encephalopathy	Susceptibility To Infection-Induced Acute Encephalopathy
Encephalopathy, Acute Necrotizing, Susceptibility To	Encephalitis, Acute Necrotizing

Leukodystrophy, Hypomyelinating, 2

Pmld1	Hypomyelinating Leukodystrophy 2
HLD2	Pelizaeus-Merzbacher-Like Disease 1
Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation	Pelizaeus-Merzbacher-Like Disease Type 1
Pelizaeus-Merzbacher-Like Disease, 1	Pelizaeus Merzbacher Like Disease
Pelizaeus-Merzbacher-Like Disease	Pmld - Pelizaeus Merzbacher Like Disease
Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1	Pmldar1
Leukodystrophy, Hypomyelinating, Type 2

Charcot-Marie-Tooth Disease, Demyelinating, Type 1a

Charcot-Marie-Tooth Disease Type 1a	CMT1A
Charcot-Marie-Tooth Disease, Type Ia	Hmsn1a
Hereditary Motor And Sensory Neuropathy Ia	Hmsn Ia
Charcot-Marie-Tooth Neuropathy, Type 1a	Charcot-Marie-Tooth Disease, Type 1a
Charcot-Marie-Tooth Neuropathy Type 1a	Hereditary Motor And Sensory Neuropathy 1a
Microduplication 17p12	Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1a
Autosomal Dominant Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 1a	Cmt 1a
Charcot Marie Tooth Disease Type 1a	Hmsn 1a
Charcot-Marie-Tooth Disease 1a	Charcot-Marie-Tooth Disease Demyelinating Type 1a
Charcot-Marie-Tooth Disease Slow Nerve Conduction Type Unlinked To Duffy

Intraocular Pressure Quantitative Trait Locus

Glaucoma	IOPQTL
Glaucoma, Susceptibility To	Postinfectious Glaucoma
Glaucoma With Ocular Inflammation	Glaucoma Secondary To Eye Inflammation
Traumatic Glaucoma	Glaucoma With Concussion Of Globe
Glaucoma Due To Ocular Trauma	Glaucoma Associated With Ocular Trauma
Glaucoma Secondary To Drugs

Nutritional Deficiency Disease

Malnutrition	Nutritional Disorder
Nutritional Deficiency	Nutrition
Deficiency Diseases	Carbamoyl-Phosphate Synthase I Deficiency Disease
Nutrition Disorders

Facial Nerve Disease

Facial Nerve Disorder	Facial Nerve Diseases
Neuropathy Of Facial Nerve	Disorders Of 7th Cranial Nerve
Disorders Of The Seventh Cranial Nerve

Facial Paralysis

Facial Palsy

Bell Palsy

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease	Dejerine-Sottas Syndrome
Charcot-Marie-Tooth Disease Type 3	DSS
Hereditary Motor And Sensory Neuropathy Type Iii	Hmsn3
Dejerine-Sottas Neuropathy	Hmsn Iii
Charcot-Marie-Tooth Disease, Type 3	Cmt3
Dsn	Hmsn 3
Hereditary Motor And Sensory Neuropathy Type 3	Hereditary Motor And Sensory Neuropathy 3
Hypertrophic Neuropathy Of Infancy	Charcot-Marie-Tooth Disease Demyelinating Type 4f
Charcot-Marie-Tooth Disease Type 4f	Charcot-Marie-Tooth Neuropathy Type 4f
Cmt4f	Hereditary Motor And Sensory Neuropathy Iii
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Small Intestine Leiomyoma

Leiomyoma, Small Bowel

Leiomyoma Of Small Intestine

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Rete Ovarii Benign Neoplasm

Rete Ovarii Adenoma

Adenoma Of Rete Ovarii

Metachromatic Leukodystrophy

Arylsulfatase A Deficiency	MLD
Arsa Deficiency	Sulfatide Lipidosis
Metachromatic Leukoencephalopathy	Cerebral Sclerosis, Diffuse, Metachromatic Form
Cerebroside Sulfatase Deficiency	Leukodystrophy, Metachromatic
Pseudoarylsulfatase A Deficiency	Leukodystrophy Metachromatic
Sulfatidosis	Metachromatic Leukodystrophy, Late Infantile
Metachromatic Leukodystrophy Variant	Deficiency Of Cerebroside-Sulfatase
Scholz Cerebral Sclerosis	Sulfatide Lipoidosis
Cerebral Sclerosis Diffuse Metachromatic Form	Arylsulfatase A Deficiency Disease
Cerebroside Sulphatase Deficiency Disease	Greenfield Disease
Metachromatic Leukodystrophy, Adult	Metachromatic Leukodystrophy, Juvenile
Leukodystrophy Metachromatic Adult	Leukodystrophy Metachromatic Juvenile
Leukodystrophy Metachromatic Late Infantile	Metachromatic Leukodystrophy, Adult Type
Metachromatic Leukodystrophy, Juvenile Type	Metachromatic Leukodystrophy, Infant
Greenfield'S Disease

Polyp Of Corpus Uteri

Endometrial/Uterine Polyp	Polyp Of Endometrium
Polyp Of The Uterus	Polyp, Uterus

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Spondylometaphyseal Dysplasia With Corneal Dystrophy

SMDCD	Spondylometaphyseal Dysplasia-Corneal Dystrophy Syndrome
Smd-Corneal Dystrophy Syndrome

Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38	SCA38
Ataxia, Spinocerebellar, Type 38

Sarcoid Meningitis

Meningitis In Sarcoidosis

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Leukodystrophy

Leukodystrophies

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0713	Amlexanox	Inhibitor	99.70%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-149687	4-Ketobenzotriazine-CH2-S-(CH2)2-COOH		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W115718	Cuprizone		99.61%	Unkown
HY-D0183	ATP-polyamine-biotin		98.06%	Unkown
HY-101525	MBP146-78	Inhibitor	99.89%	Unkown
HY-144088	ZYF0033	Inhibitor	98.86%	Unkown
HY-P2456	MBP MAPK Substrate		99.58%	Unkown
HY-133512	NCGC00249987	Inhibitor	99.58%	Unkown
HY-168534	WX-02-23		99.88%	Unkown
HY-P10532	Myelin basic protein, MBP (68-86)		99.28%	Unkown
HY-128749A	D-Glucaric acid tetrahydrate	Inducer	99.87%	Unkown
HY-112219A	H3R antagonist 1 hydrochloride	Inhibitor	99.10%	Unkown
HY-112219	H3R antagonist 1	Inhibitor	99.21%	Unkown
HY-P10428	E6AP-mimicking peptide	Inhibitor	/	Unkown
HY-P1289	[Ala113]MBP(104-118)	Inhibitor	/	Unkown
HY-P1289A	[Ala107]MBP(104-118)	Inhibitor	/	Unkown
HY-P1289B	[Ala107]MBP(104-118) TFA	Inhibitor	/	Unkown
HY-P1289C	[Ala113]MBP(104-118) TFA	Inhibitor	/	Unkown
HY-P1289D	[Ala107]MBP(104-118) acetate	Inhibitor	/	Unkown
HY-P1734	Ac-MBP (1-11)		/	Unkown
HY-P3248	J5 peptide		/	Unkown
HY-P3723	MBP (83-99)		/	Unkown
HY-P3940	Ac-MBP (4-14) Peptide		/	Unkown
HY-RS08188	MBL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08196	MBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11088	PRG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16624	Mbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19939	Prg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23059	Mbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991450	ADI-15878	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MBP	MGD	MGI:96925
Canis familiaris	MBP	VGNC	VGNC:53736
Rattus norvegicus	MBP	RGD	RGD:3054
Felis catus	MBP	VGNC	VGNC:80453
Macaca mulatta	MBP	VGNC	VGNC:74673
Bos taurus	MBP	VGNC	VGNC:54450
Canis lupus familiaris	MBP	NCBI
Others	MBP	NCBI