Rc3h1 - RING CCCH (C3H) domains 1 Gene

Mus musculus

Also known as Gm551; mKIAA2025; 5730557L09Rik

Gene ID: 381305 | Gene type: protein coding

About Rc3h1

Summary

Enables RNA binding activity and zinc ion binding activity. Involved in several processes, including P-body assembly; negative regulation of lymphocyte activation; and regulation of RNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Located in P-body and cytoplasmic stress granule. Used to study peripheral T-cell lymphoma and systemic lupus erythematosus. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Rc3h1 Products(1)

mRNA	Protein	Name
NM_001024952.2	NP_001020123.1	roquin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	25026077	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	20639877	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	23583643	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	25697406	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20639877	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	25697406	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	26000482	MGI
acts upstream of or within B cell homeostasis	IGI IGI: Inferred from genetic interaction	23583643	MGI
involved in P-body assembly	IMP IMP: Inferred from mutant phenotype	20639877	MGI
acts upstream of or within T cell homeostasis	IGI IGI: Inferred from genetic interaction	23583643	MGI
acts upstream of or within T cell proliferation	IGI IGI: Inferred from genetic interaction	23583643	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25282160	MGI
acts upstream of or within T follicular helper cell differentiation	IGI IGI: Inferred from genetic interaction	23583643	MGI
acts upstream of or within lymph node development	IGI IGI: Inferred from genetic interaction	23583643	MGI
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	18172933	MGI
involved in negative regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	25282160	MGI
acts upstream of or within negative regulation of T-helper cell differentiation	IMP IMP: Inferred from mutant phenotype	15917799	MGI
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18172933	MGI
involved in negative regulation of germinal center formation	IMP IMP: Inferred from mutant phenotype	18172933	MGI
involved in nuclear-transcribed mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	20639877	MGI
involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	26000482	MGI
involved in positive regulation of mRNA catabolic process	IDA IDA: Inferred from direct assay	26000482	MGI
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	25026077	MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23583643	MGI
acts upstream of or within post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	23583643	MGI
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20639877	MGI
involved in regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15917799	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	23583643	MGI
involved in regulation of germinal center formation	IMP IMP: Inferred from mutant phenotype	15917799	MGI
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	18172933	MGI
involved in regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	25697406	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	23583643	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	20639877	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15917799	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	15917799	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

roquin-1

RING finger and C3H zinc finger protein 1	RING finger and CCCH-type zinc finger domain-containing protein 1
probable E3 ubiquitin-protein ligase Roquin	protein Sanroque
roquin

Rc3h1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rc3h1	Q4VGL6	Edc4	Mus musculus	Q3UJB9	Anti Bait CoIP	20639877
Intra	Rc3h1	Q4VGL6	Ago2	Mus musculus	Q8CJG0	Anti Bait CoIP	25697406
Intra	Rc3h1	Q4VGL6	Ago2	Mus musculus	Q8CJG0	Anti Tag CoIP	25697406

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11777	RC3H1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rc3h1	NCBI	NCBI:149041

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