Rac1 - Rac family small GTPase 1 Gene

Rattus norvegicus

Gene ID: 363875 | Gene type: protein coding

About Rac1

Summary

Enables several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including Rac protein signal transduction; bone resorption; and regulation of cellular biosynthetic process. Located in several cellular components, including Golgi membrane; cytosol; and dendritic spine. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rac1 Products(1)

mRNA	Protein	Name
NM_134366.1	NP_599193.1	ras-related C3 botulinum toxin substrate 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	20671235	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	12672819	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	12672819	RGD
enables Rho GDP-dissociation inhibitor binding	IPI IPI: Inferred from physical interaction	22564631	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	22679019	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15608632	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20861382	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	16040606	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	10350213	RGD
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	12413953	RGD
involved in bone resorption	IDA IDA: Inferred from direct assay	10350213	RGD
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	12105187	RGD
involved in chemotaxis	IMP IMP: Inferred from mutant phenotype	11756405	RGD
involved in mast cell chemotaxis	IMP IMP: Inferred from mutant phenotype	12413953	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9487126	RGD
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	15788770	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	23412604	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	12105187	RGD
involved in postsynaptic actin cytoskeleton organization	EXP EXP: Inferred from Experiment	25284783	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	25284783	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25284783	RGD
involved in regulation of nitric oxide biosynthetic process	IGI IGI: Inferred from genetic interaction	16055727	RGD
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	20696765	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	25284783	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25284783	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25284783	RGD
located in Golgi membrane	IDA IDA: Inferred from direct assay	15147909	RGD
located in cytosol	IDA IDA: Inferred from direct assay	20696765	RGD
located in membrane	IDA IDA: Inferred from direct assay	20696765	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related C3 botulinum toxin substrate 1

p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
rho family, small GTP binding protein Rac1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112842	MBQ-167	Inhibitor	99.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (72)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18723	Yoda 1		99.98%	Unkown
HY-15723A	NSC 23766 trihydrochloride		99.41%	Unkown
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-12755	ML141		99.96%	Unkown
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-100047	Nα,Nα-Bis(carboxymethyl)-L-lysine		98.80%	Unkown
HY-124306	ML-099	Activator	99.75%	Unkown
HY-125792	Nexinhib20	Inhibitor	99.86%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-110100	CPYPP	Inhibitor	99.94%	Unkown
HY-118208	ML-097	Inhibitor	99.90%	Unkown
HY-N0710	alpha-Cyperone		99.68%	Unkown
HY-U00145	Digeranyl bisphosphonate	Inhibitor	99.07%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-136383	AZA1		98.17%	Unkown
HY-113849	MLS-573151	Inhibitor	99.70%	Unkown
HY-B0580B	(R)-Ketorolac	Inhibitor	99.65%	Unkown
HY-102078	ZINC69391		99.76%	Unkown
HY-119576	Phox-I2	Inhibitor	99.52%	Unkown
HY-112307A	(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium		99.97%	Unkown
HY-158304	Rac1-IN-4	Inhibitor	98.61%	Unkown
HY-133146	DJ001	Inhibitor	99.92%	Unkown
HY-120213	YH-306		98.34%	Unkown
HY-12646A	Rhosin		95.08%	Unkown
HY-107501	(Rac)-1-Oleoyl lysophosphatidic acid sodium	Control	≥98.0%	Unkown
HY-P1382A	Rac1 Inhibitor W56 TFA	Inhibitor	99.92%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-156668	Rac1-IN-3	Inhibitor	98.28%	Unkown
HY-RS11591	RAC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-143699S	(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5		97.62%	Unkown
HY-152095	PPI-GIT1/β-Pix PPI-IN-1	Inhibitor	99.01%	Unkown
HY-50733A	CX-5011		/	Unkown
HY-W013060	(Rac)-1,2-Dilinoleoyl-3-palmitoyl-glycerol		≥99.0%	Unkown
HY-W127391	1,2-Dilaurin		≥98.0%	Unkown
HY-W127550	1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium		/	Unkown
HY-50733	CX-5011 free base		/	Unkown
HY-109541S6	(Rac)-Colfosceril miristate-d72		/	Unkown
HY-120229	GGTI-2147	Inhibitor	/	Unkown
HY-131598C	6-Thio-GTP tetrasodium	Inhibitor	/	Unkown
HY-137862A	(Rac)-1-Oleoyl lysophosphatidic acid	Control	/	Unkown
HY-147076	20:4 PG sodium		/	Unkown
HY-167569	(Rac)-1-Palmitoyl-glycero-3-phosphocholine		/	Unkown
HY-170458	18:0-18:2 PG sodium		/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-P10038	mP6	Inhibitor	/	Unkown
HY-P10107	TAT-PAK18 R192A	Control	/	Unkown
HY-P1382	Rac1 Inhibitor W56	Inhibitor	/	Unkown
HY-P1383A	Rac1 Inhibitor F56, control peptide TFA	Inhibitor	/	Unkown
HY-RS12018	RNASE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W127356	(Rac)-1,2-Distearoyl-3-chloropropanediol-d5		/	Unkown
HY-W127363	(Rac)-1,2-Dihexadecylglycerol		/	Unkown
HY-W127415	rac-1-Stearoyl-3-chloropropanediol		/	Unkown
HY-W127415S	(Rac)-1-Stearoyl-3-chloropropanediol-d5		/	Unkown
HY-W127570	rac-1,2-Distearoyl-3-chloropropanediol		/	Unkown
HY-W587715S	(Rac)-1,2-Dioleoyl-3-chloropropanediol-d5		/	Unkown
HY-W653931	rac 1,2-Bis-palmitoyl-3-chloropropanediol-13C3		/	Unkown
HY-W767222	rac-1-Linoleoyl-2-chloropropanediol-d5		/	Unkown
HY-W767223	rac 1-Palmitoyl-2-chloropropanediol-d5		/	Unkown
HY-W770200	rac 1-Oleoyl-2,3-isopropylidieneglycerol-d5		/	Unkown
HY-W777103	(Rac)-1-Oleoyl-3-linoleoyl-glycerol		/	Unkown
HY-W777682	(Rac)-1-Linoleoyl-2,3-isopropylidene-glycerol		/	Unkown
HY-W777871	rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-134243	6-T-GDP	Inhibitor	/	Unkown
HY-RS16742	Rac1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23179	Rac1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W702728	rac 1-Palmitoyl-2-chloropropanediol		/	Unkown
HY-W749756	rac-1,2-Distearoyl-3-chloropropanediol-13C3		/	Unkown
HY-W766801	rac-1-Linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W766807	rac-1,2-Dilinoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W766831	rac 1-oleoyl-2-linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W777866	(Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rac1	NCBI	NCBI:5879

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