Lck - LCK proto-oncogene, Src family tyrosine kinase Gene

Rattus norvegicus

Also known as Lck1; Lcktkr

Gene ID: 313050 | Gene type: protein coding

About Lck

Summary

Enables antigen binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of uterine smooth muscle contraction; protein phosphorylation; and response to hydrogen peroxide. Located in endocytic vesicle; membrane raft; and plasma membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study allergic conjunctivitis and human immunodeficiency virus infectious disease. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human Lck (Lck proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lck Products(1)

mRNA	Protein	Name
NM_001100709.1	NP_001094179.1	proto-oncogene tyrosine-protein kinase LCK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antigen binding	IPI IPI: Inferred from physical interaction	18178839	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	11034334	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8104794	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11034334	RGD
involved in positive regulation of uterine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	19208792	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11034334	RGD
involved in response to aldosterone	IEP IEP: Inferred from expression pattern	29713904	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	9325251	RGD
involved in response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	19208792	RGD
involved in response to metal ion	IDA IDA: Inferred from direct assay	11477538	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	14652378	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endocytic vesicle	IDA IDA: Inferred from direct assay	9116282	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14529711	RGD
is active in postsynaptic specialization, intracellular component	IDA IDA: Inferred from direct assay	14529711	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proto-oncogene tyrosine-protein kinase LCK

lymphocyte cell-specific protein-tyrosine kinase	lymphocyte protein tyrosine kinase
lymphocyte-specific protein tyrosine kinase	p56-LCK

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Phase 2
HY-157442	GLPG3312	Inhibitor	98.57%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132166	M4205	Inhibitor	99.47%	Unkown
HY-13561	AZM475271	Inhibitor	99.89%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-112291	SB 220025	Inhibitor	99.90%	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-163278	Lck-IN-2	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lck	NCBI	NCBI:3932

Name
Email *

	Sorry, but the email address you supplied was invalid.