Axl - Axl receptor tyrosine kinase Gene

Rattus norvegicus

Gene ID: 308444 | Gene type: protein coding

About Axl

Summary

Enables Myosin heavy chain binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including animal organ regeneration; cellular response to hydrogen peroxide; and negative regulation of apoptotic process. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Used to study glomerulonephritis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human Axl (Axl receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Axl Products(2)

mRNA	Protein	Name
NM_001013147.2	NP_001013165.2	tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_031794.2	NP_113982.2	tyrosine-protein kinase receptor UFO isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables myosin heavy chain binding	IPI IPI: Inferred from physical interaction	20479336	RGD
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	18292389	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	16285961	RGD
involved in cell differentiation	IMP IMP: Inferred from mutant phenotype	20479336	RGD
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20479336	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15380678	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	20187850	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase receptor UFO

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.96%	Yes
HY-12432	Gilteritinib	Inhibitor	99.84%	Yes
HY-12432A	Gilteritinib hemifumarate	Inhibitor	99.75%	Yes
HY-13016A	Cabozantinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-138696	Zanzalintinib	Inhibitor	99.91%	Phase 3
HY-15150	Bemcentinib	Inhibitor	99.92%	Phase 2
HY-12963	Dubermatinib	Inhibitor	99.84%	Phase 2
HY-12076	BMS 777607	Inhibitor	99.36%	Phase 2
HY-114358	Tamnorzatinib	Inhibitor	98.59%	Phase 2
HY-107145A	Ningetinib	Inhibitor	99.82%	Phase 2
HY-107145	Ningetinib Tosylate	Inhibitor	99.59%	Phase 2
HY-100946	CEP-40783	Inhibitor	99.61%	Phase 1

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99463	Batiraxcept		99.91%	Phase 3
HY-P99360	Enapotamab	Inhibitor	≥99.0%	Phase 2
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114166	2-D08	Inhibitor	99.17%	Unkown
HY-12494	LDC1267	Inhibitor	99.64%	Unkown
HY-15797	UNC2250	Inhibitor	99.92%	Unkown
HY-117596	UNC569	Inhibitor	99.92%	Unkown
HY-132200	UNC5293	Inhibitor	99.93%	Unkown
HY-117548	UNC1062	Inhibitor	98.92%	Unkown
HY-12964	SGI-7079	Inhibitor	99.32%	Unkown
HY-15798	UNC2881	Inhibitor	99.79%	Unkown
HY-124066	RU-302	Inhibitor	98.72%	Unkown
HY-100509	NPS-1034	Inhibitor	≥98.0%	Unkown
HY-13016S	Cabozantinib-d6	Inhibitor	98.14%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-144627	PROTAC Axl Degrader 2	Inhibitor	98.01%	Unkown
HY-151904	AXL-IN-13	Inhibitor	98.03%	Unkown
HY-147218	PF-07265807	Inhibitor	97.13%	Unkown
HY-150041	TL4830031	Inhibitor	≥98.0%	Unkown
HY-132893	AZ14145845	Inhibitor	/	Unkown
HY-146615	Axl-IN-6	Inhibitor	/	Unkown
HY-176204	Axl-IN-19	Inhibitor	/	Unkown
HY-144708	Axl-IN-4	Inhibitor	/	Unkown
HY-153441	AXL-IN-15	Inhibitor	/	Unkown
HY-149092	Anticancer agent 109		/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-N12041	Axl-IN-16	Inhibitor	/	Unkown
HY-15150G	Bemcentinib (GMP)	Inhibitor	/	Unkown
HY-104075	R916562	Inhibitor	/	Unkown
HY-173400	UNC8212	Inhibitor	/	Unkown
HY-144706	Axl-IN-3	Inhibitor	/	Unkown
HY-173268	UNC9426	Inhibitor	/	Unkown
HY-147577	Axl-IN-10	Inhibitor	/	Unkown
HY-162085	Axl-IN-17	Inhibitor	/	Unkown
HY-147574	Axl-IN-7	Inhibitor	/	Unkown
HY-144624	PROTAC Axl Degrader 1	Inhibitor	/	Unkown
HY-147579	Axl-IN-12	Inhibitor	/	Unkown
HY-147578	Axl-IN-11	Inhibitor	/	Unkown
HY-146596	Axl-IN-5	Inhibitor	/	Unkown
HY-147575	Axl-IN-8	Inhibitor	/	Unkown
HY-147576	Axl-IN-9	Inhibitor	/	Unkown
HY-149491	HIV-IN-7	Inhibitor	/	Unkown
HY-152075	AXL-IN-14	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99733	Mipasetamab	Inhibitor	98.26%	Unkown
HY-P9988	Mecbotamab	Inhibitor	99.10%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Axl	NCBI	NCBI:558
Macaca fascicularis	Axl	NCBI	NCBI:102126361
Mus musculus	Axl	NCBI	NCBI:26362

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