2. Protein Tyrosine Kinase/RTK Antibody-drug Conjugate/ADC Related
  3. TAM Receptor ADC Antibody
  4. Enapotamab

Enapotamab  (Synonyms: Anti-AXL/UFO Reference Antibody (enapotamab))

Cat. No.: HY-P99360 Purity: ≥99.0%
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Enapotamab (Anti-AXL/UFO Reference Antibody) is an AXL/UFO-related antibody that can be used for synthesis of ADC molecule Enapotamab vedotin (HY-P99921).

For research use only. We do not sell to patients.

CAS No. : 1912423-61-0

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Based on 1 publication(s) in Google Scholar

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Description

Enapotamab (Anti-AXL/UFO Reference Antibody) is an AXL/UFO-related antibody that can be used for synthesis of ADC molecule Enapotamab vedotin (HY-P99921)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

Axl

 

In Vitro

Enapotamab can be used as the ADC antibody of Enapotamab vedotin (HY-P99921).
Enapotamab vedotin exhibits cytotoxicity in AXL high expressing NSCLC cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enapotamab Related Antibodies
In Vivo

Enapotamab vedotin exhibits antitumor efficacy against various NSCLC tumors with high AXL expression, also exhibits resistant to EGFR inhibitor in LU1868 xenograft mouse models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

143.895 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Enapotamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Enapotamab on AHC2 biosensor, can bind AXL Protein, Human (449a.a, HEK293, His, HY-P74407) with an affinity constant of 6.653E-09 M as determined in BLI assay.
  • Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Enapotamab. The EC50 for this effect is 0.3126 ng/mL.
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (232 KB) SDS-PAGE (89 KB) SEC-HPLC (68 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Enapotamab Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enapotamab1912423-61-0Anti-AXL/UFO Reference Antibody (enapotamab)TAM ReceptorADC AntibodyTyro3AxlMerInhibitorinhibitorinhibit

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