2. Gene
  3. Akr1c1 - aldo-keto reductase family 1, member C1 Gene

Akr1c1 - aldo-keto reductase family 1, member C1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Akr1c6; Hsd17b5

Gene ID: 307092 | Gene type: protein coding

About Akr1c1

Summary

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c1 Products(1)

mRNA Protein Name
NM_001033697.1 NP_001028869.1 aldo-keto reductase family 1, member C1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
IDA: Inferred from direct assay
16788056 RGD
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
16788056 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to estrogen IDA
IDA: Inferred from direct assay
16788056 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16788056 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18574251 RGD
located in nucleus IDA
IDA: Inferred from direct assay
18574251 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1, member C1

20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1

20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

aldo-keto reduc

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 Inhibitor 98.35% Unkown
HY-114009 AKR1C1-IN-1 Inhibitor 99.38% Unkown
HY-D1341 Coumberone 99.95% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown
HY-113850 CPSA Inhibitor / Unkown
HY-131586 3,7-Dihydroxyflavone / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-172598 Keap1-Nrf2-IN-28 Inhibitor / Unkown
HY-173132 AKR1Cs-IN-1 Inhibitor / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1c1 NCBI NCBI:1645