AKR1C1 - aldo-keto reductase family 1 member C1 Gene

Homo sapiens

Also known as C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD

Gene ID: 1645 | Gene type: protein coding

About AKR1C1

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:4,963,415-4,983,283 (from NCBI)

This gene has 5 transcripts (splice variants), 491 orthologues and 16 paralogues. Biased expression in liver (RPKM 85.2), fat (RPKM 74.3) and 13 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three Other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

AKR1C1 Products(1)

mRNA	Protein	Name
NM_001353.6	NP_001344.2	aldo-keto reductase family 1 member C1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aldose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables androsterone dehydrogenase (B-specific) activity	IDA IDA: Inferred from direct assay	8486699	GOA
enables bile acid binding	IDA IDA: Inferred from direct assay	8486699	GOA
enables carboxylic acid binding	IDA IDA: Inferred from direct assay	8486699	GOA
enables ketosteroid monooxygenase activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	19442656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	IDA IDA: Inferred from direct assay	8486699	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid metabolic process	IDA IDA: Inferred from direct assay	8486699	GOA
involved in cellular response to jasmonic acid stimulus	IDA IDA: Inferred from direct assay	19487289	GOA
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in digestion	IDA IDA: Inferred from direct assay	8486699	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	21492153	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in progesterone metabolic process	IDA IDA: Inferred from direct assay	21232532	GOA
involved in response to organophosphorus	IEP IEP: Inferred from expression pattern	16079077	GOA
involved in retinal metabolic process	IDA IDA: Inferred from direct assay	21851338	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	8486699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1C1 Protein Structure

Aldo_ket_red

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

aldo-keto reductase family 1 member C1

20 alpha-hydroxysteroid dehydrogenase

AKR1C1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKR1C1	Q04828	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	32296183
Intra	AKR1C1	Q04828	PTPN3	Homo sapiens	P26045	Validated Y2H	25416956
Intra	AKR1C1	Q04828	PTPN3	Homo sapiens	P26045	Y2H Array	25416956
Intra	AKR1C1	Q04828	AKR1D1	Homo sapiens	P51857	Anti Tag CoIP	33961781
Intra	AKR1C1	Q04828	AKR1D1	Homo sapiens	P51857	Anti Tag CoIP	28514442
Intra	AKR1C1	Q04828	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	AKR1C1	Q04828	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	AKR1C1	Q04828	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

AKR1C1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82930	AKR1C1/AKR1C2 Antibody (YA2675)	WB, FC	Human, Mouse, Rat
HY-P84483	AKR1C1 Antibody (YA4180)	WB, IHC-P, FC	Human, Mouse, Rabbit

Related Diseases

Diseases

Alias

Developmental Dysplasia Of The Hip 1

Acetabular Dysplasia	Developmental Dysplasia Of The Hip
DDH1	Hip Dysplasia, Developmental
Ddh	Hip Dysplasia, Congenital
Cdh	Congenital Hip Dislocation Nos

Lipedema

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Lung Benign Neoplasm

Lung Neoplasms	Tumor Of The Lung
Lung Tumor

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0376	Liquiritin		99.99%	Unkown
HY-150644	S07-2010	Inhibitor	99.79%	Unkown
HY-114009	AKR1C1-IN-1	Inhibitor	99.38%	Unkown
HY-D1341	Coumberone		99.95%	Unkown
HY-118819	5-Bromo-3-phenyl salicylic acid	Inhibitor	98.00%	Unkown
HY-113850	CPSA	Inhibitor	/	Unkown
HY-131586	3,7-Dihydroxyflavone		/	Unkown
HY-163609	PROTAC AKR1C3 degrader-1	Degrader	/	Unkown
HY-172598	Keap1-Nrf2-IN-28	Inhibitor	/	Unkown
HY-173132	AKR1Cs-IN-1	Inhibitor	/	Unkown
HY-N0376R	Liquiritin (Standard)		/	Unkown
HY-RS00534	AKR1C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23471	Akr1c1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR1C1	RGD	RGD:1306847

Name
Email *

	Sorry, but the email address you supplied was invalid.