Ldlr - low density lipoprotein receptor Gene

Rattus norvegicus

Also known as LDLRA

Gene ID: 300438 | Gene type: protein coding

About Ldlr

Summary

Enables low-density lipoprotein particle receptor activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ldlr Products(1)

mRNA	Protein	Name
NM_175762.3	NP_786938.2	low-density lipoprotein receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables low-density lipoprotein particle receptor activity	IDA IDA: Inferred from direct assay	3559401	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15044370	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol homeostasis	IEP IEP: Inferred from expression pattern	20028367	RGD
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	17256088	RGD
involved in positive regulation of triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	28469073	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	3559401	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15044370	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20028367	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	19008317	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	17572141	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18703410	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	12646183	RGD
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	10468577	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor

LDL receptor

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106539	Colesevelam hydrochloride		98.00%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4073	ANG1005		98.83%	Phase 3
HY-152857	Muvalaplin	Inhibitor	99.96%	Phase 2
HY-109567	Gemcabene	Inhibitor	99.91%	Phase 2
HY-109567A	Gemcabene calcium	Inhibitor	≥98.0%	Phase 2
HY-116175	BIBB 515		99.44%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99822	Recaticimab		99.71%	Phase 3
HY-P99793	Orticumab	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-NP013	Oxidized low density lipoprotein (mouse)		≥98.0%	Unkown
HY-P2341	Angiopep-2 hydrochloride		99.74%	Unkown
HY-145001	20-HC-Me-Pyrrolidine	Inhibitor	99.69%	Unkown
HY-101529	Imanixil		99.03%	Unkown
HY-125544	LY 295427	Modulator	≥98.0%	Unkown
HY-120651	LDL-IN-2	Inhibitor	≥99.0%	Unkown
HY-NP012	Low density lipoprotein (human)		/	Unkown
HY-W015600	2-Acetamidophenol	Inhibitor	99.48%	Unkown
HY-A0127	Etofibrate	Activator	99.80%	Unkown
HY-100144	Pirozadil		98.31%	Unkown
HY-U00054	LDL-IN-3	Inhibitor	/	Unkown
HY-P10697	VH4127	Modulator	/	Unkown
HY-161941	MeIm		/	Unkown
HY-P10911	IETP2	Ligand	/	Unkown
HY-172661	Kylo-0603	Inhibitor	/	Unkown
HY-P10502	L57		/	Unkown
HY-167870	Piceatannol 4'-O-glucoside	Inhibitor	/	Unkown
HY-113288	Campestanol	Inhibitor	≥99.0%	Unkown
HY-W423578	LDLR regulator-1	Modulator	/	Unkown
HY-126551	Butenoyl-PAF		/	Unkown
HY-147279	Milpocitide		/	Unkown
HY-167873	Habenariol	Inhibitor	/	Unkown
HY-115914	Lipid-lowering agent-1		/	Unkown
HY-P10698	VH-N412		/	Unkown
HY-165512	Nicanartine	Inhibitor	/	Unkown
HY-123260	S12340	Inhibitor	/	Unkown
HY-138089	17β-Hydroxy exemestane	Inhibitor	/	Unkown
HY-159595	PCSK9-IN-29	Inducer	99.44%	Unkown
HY-161938	BRD8518		/	Unkown
HY-164412	Phosphatidylcholine (C18:2,C20:4)	Activator	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990143	Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6)	Inhibitor	95.00%	Unkown
HY-P990480	Anti-oxLDL Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ldlr	NCBI	NCBI:3949
Macaca fascicularis	Ldlr	NCBI	NCBI:102127361
Mus musculus	Ldlr	NCBI	NCBI:16835

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