2. Gene
  3. C8a - complement C8 alpha chain Gene

C8a - complement C8 alpha chain Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 298288 | Gene type: protein coding

About C8a

Summary

Enables complement binding activity. Predicted to be involved in complement activation, classical pathway; cytolysis; and innate immune response. Predicted to act upstream of or within complement activation. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in type I Complement Component 8 deficiency. Orthologous to human C8A (complement C8 alpha chain). [provided by Alliance of Genome Resources, Apr 2022]

C8a Products(1)

mRNA Protein Name
NM_001106670.1 NP_001100140.1 complement component C8 alpha chain precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables complement binding IPI
IPI: Inferred from physical interaction
3312411 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
3312411 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular region IDA
IDA: Inferred from direct assay
3312411 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
3312411 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement component C8 alpha chain

complement component 8 alpha subunit

complement component 8, alpha polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01755 C8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17136 C8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23582 C8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C8a NCBI NCBI:731
Macaca fascicularis C8a NCBI NCBI:102133722
Mus musculus C8a NCBI NCBI:230558