2. Gene
  3. C8a - complement component 8, alpha polypeptide Gene

C8a - complement component 8, alpha polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 230558 | Gene type: protein coding

About C8a

Summary

This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015]

C8a Products(6)

mRNA Protein Name
NM_001290645.2 NP_001277574.1 complement component C8 alpha chain isoform 2
NM_001316667.1 NP_001303596.1 complement component C8 alpha chain isoform 3 precursor
NM_146148.2 NP_666260.1 complement component C8 alpha chain isoform 1 preproprotein
NM_001290645.2 NP_001277574.1 complement component C8 alpha chain isoform 2
NM_001316667.1 NP_001303596.1 complement component C8 alpha chain isoform 3 precursor
NM_146148.2 NP_666260.1 complement component C8 alpha chain isoform 1 preproprotein
Protein Preferred Names Protein Names

complement component C8 alpha chain

complement component 8 alpha subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01755 C8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17136 C8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23582 C8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C8a NCBI NCBI:731
Macaca fascicularis C8a NCBI NCBI:102133722
Rattus norvegicus C8a NCBI NCBI:298288