Prkar2a - protein kinase cAMP-dependent type II regulatory subunit alpha Gene

Rattus norvegicus

Gene ID: 29699 | Gene type: protein coding

About Prkar2a

Summary

Enables several functions, including beta-2 Adrenergic Receptor binding activity; cAMP binding activity; and cAMP-dependent protein kinase regulator activity. Involved in regulation of protein kinase activity and response to clozapine. Located in T-tubule and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkar2a Products(1)

mRNA	Protein	Name
NM_019264.2	NP_062137.1	cAMP-dependent protein kinase type II-alpha regulatory subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-2 adrenergic receptor binding	IPI IPI: Inferred from physical interaction	20395454	RGD
enables cAMP binding	IDA IDA: Inferred from direct assay	11907174	RGD
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	11907174	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17081990	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10618500	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	16306226	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17081990	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17081990	RGD
enables small molecule binding	IDA IDA: Inferred from direct assay	21177871	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11907174	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	14569017	RGD
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	11907174	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18550536	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17081990	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase type II-alpha regulatory subunit

protein kinase cAMP-dependent type 2 regulatory subunit alpha	protein kinase, cAMP dependent regulatory, type II alpha
protein kinase, cAMP-dependent, regulatory subunit type II alpha	protein kinase, cAMP-dependent, regulatory, type 2, alpha

Prkar2a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Prkar2a	P12368	PDE4DIP	Homo sapiens	Q5VU43-11	Anti Bait CoIP	21569246
Cross	Prkar2a	P12368	PDE4DIP	Homo sapiens	Q5VU43-11	Anti Tag CoIP	21569246

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11114	PRKAR2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22020	Prkar2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28538	Prkar2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkar2a	NCBI	NCBI:5576

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