2. Gene
  3. Itgav - integrin subunit alpha V Gene

Itgav - integrin subunit alpha V Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cd51

Gene ID: 296456 | Gene type: protein coding

About Itgav

Summary

Enables signaling receptor binding activity. Involved in several processes, including blood vessel morphogenesis; positive regulation of cell population proliferation; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including cell projection membrane; external side of plasma membrane; and focal adhesion. Predicted to be part of alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and Integrin complex. Used to study corneal neovascularization; coronary stenosis; and ischemia. Biomarker of hypertension. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (Integrin subunit alpha V). [provided by Alliance of Genome Resources, Apr 2022]

Itgav Products(2)

mRNA Protein Name
NM_001398692.1 NP_001385621.1 integrin alpha-V isoform 1 precursor
NM_001398693.1 NP_001385622.1 integrin alpha-V isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
1585837 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21969374 RGD
Biological Process GO Annotation Evidence Reference Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
12926533 RGD
involved in cell migration IMP
IMP: Inferred from mutant phenotype
16565398 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11953315 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
17072743 RGD
involved in vasculogenesis IEP
IEP: Inferred from expression pattern
12926533 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-V

Dnmt3l-ps1 pseudogene

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990667 STX-100 Inhibitor 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06961 ITGAV Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16754 Itgav Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23193 Itgav Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990667B STX-100 (Biotinylated) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgav NCBI NCBI:3685
Macaca fascicularis Itgav NCBI NCBI:102116249
Mus musculus Itgav NCBI NCBI:16410
Macaca mulatta Itgav NCBI NCBI:707756