2. Gene
  3. Vps18 - VPS18 core subunit of CORVET and HOPS complexes Gene

Vps18 - VPS18 core subunit of CORVET and HOPS complexes Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 296083 | Gene type: protein coding

About Vps18

Summary

Predicted to enable several functions, including actin binding activity; syntaxin binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including endosome to lysosome transport; negative regulation of intracellular Estrogen receptor signaling pathway; and vesicle docking involved in exocytosis. Predicted to act upstream of or within viral entry into host cell. Is active in presynapse. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]

Vps18 Products(1)

mRNA Protein Name
NM_001106499.2 NP_001099969.1 vacuolar protein sorting-associated protein 18 homolog
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14668490 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in presynapse IDA
IDA: Inferred from direct assay
17027648 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 18 homolog

VPS18 CORVET/HOPS core subunit

vacuolar protein sorting 18 homolog

Vps18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Vps18 B5DFJ4 Hook1 Rattus norvegicus D3ZB48
Anti Bait CoIP
14668490
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15677 VPS18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21082 Vps18 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27599 Vps18 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vps18 NCBI NCBI:57617