Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

Rattus norvegicus

Also known as Trpm2-predicted

Gene ID: 294329 | Gene type: protein coding

About Trpm2

Summary

Predicted to enable calcium ion binding activity; metal ion transmembrane transporter activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including calcium ion import across plasma membrane; estrous cycle; and positive regulation of Insulin secretion. Located in neuron projection; neuronal cell body; and plasma membrane. Biomarker of transient cerebral ischemia. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Apr 2022]

Trpm2 Products(1)

mRNA	Protein	Name
NM_001011559.2	NP_001011559.2	transient receptor potential cation channel subfamily M member 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	16651700	RGD
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	16651700	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	24577155	RGD
involved in positive regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16651700	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	16601673	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	16651700	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 2

transient receptor potential melastatin family 2

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-14600	Rosiglitazone maleate	99.73%	Yes
HY-14600R	Rosiglitazone maleate (Standard)	/	Unkown
HY-B0700	Rosiglitazone sodium	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100973A	Adenosine 5′-diphosphoribose sodium		99.47%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110220	CIM0216	Agonist	99.94%	Unkown
HY-149143	JNJ-28583113	Inhibitor	98.82%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-113037C	Farnesyl pyrophosphate ammonium	Agonist	≥95.0%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N7395	Cyclic ADP-ribose	Activator	≥96.0%	Unkown
HY-N7395A	Cyclic ADP-ribose ammonium	Activator	99.38%	Unkown
HY-113037	(E/Z)-Farnesyl pyrophosphate	Agonist	/	Unkown
HY-134261	8-Br-ADPR		/	Unkown
HY-173449	TRPM2-IN-1	Inhibitor	/	Unkown
HY-P5883	TAT-M2NX	Inhibitor	/	Unkown
HY-RS02848	CLU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15112	TRPM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117804	8-Br-cADPR	Antagonist	/	Unkown
HY-134268	8-Br-7-CH-ADPR	Antagonist	/	Unkown
HY-137704	2′-Deoxy-ADPR	Agonist	/	Unkown
HY-RS16755	Trpm2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23194	Trpm2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23774	Clu Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpm2	NCBI	NCBI:7226

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