Hpca - hippocalcin Gene

Rattus norvegicus

Gene ID: 29177 | Gene type: protein coding

About Hpca

Summary

Enables calcium ion binding activity and kinase binding activity. Involved in several processes, including activation of Phospholipase D activity; cellular response to electrical stimulus; and negative regulation of Guanylate Cyclase activity. Located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Is extrinsic component of membrane. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Apr 2022]

Hpca Products(1)

mRNA	Protein	Name
NM_017122.2	NP_058818.1	neuron-specific calcium-binding protein hippocalcin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	1543495	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	23142228	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16470652	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of phospholipase D activity	IDA IDA: Inferred from direct assay	11211872	RGD
involved in calcium-mediated signaling	IEP IEP: Inferred from expression pattern	20704590	RGD
involved in cellular response to L-glutamate	IDA IDA: Inferred from direct assay	20704590	RGD
involved in cellular response to electrical stimulus	IEP IEP: Inferred from expression pattern	20704590	RGD
involved in negative regulation of guanylate cyclase activity	IDA IDA: Inferred from direct assay	15336960	RGD
involved in positive regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	15336960	RGD
involved in positive regulation of phospholipase activity	IDA IDA: Inferred from direct assay	11211872	RGD
involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	23142228	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	20852624	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	20852624	RGD
involved in response to Aroclor 1254	IEP IEP: Inferred from expression pattern	18602130	RGD
involved in response to L-glutamate	IEP IEP: Inferred from expression pattern	20704590	RGD
involved in response to ketamine	IEP IEP: Inferred from expression pattern	12614903	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18602130	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	7789406	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	7789406	RGD
located in cytosol	IDA IDA: Inferred from direct assay	1543495	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	8233019	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	8233019	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	20704590	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20704590	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20704590	RGD
located in membrane	IDA IDA: Inferred from direct assay	1543495	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	8233019	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	8233019	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	20704590	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	20704590	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuron-specific calcium-binding protein hippocalcin

P23K	calcium-binding protein

Hpca Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Hpca	P84076	PDE1A	Bos taurus	P14100	Pull Down	16470652

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06333	HPCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17810	Hpca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24278	Hpca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hpca	NCBI	NCBI:3208
Mus musculus	Hpca	NCBI	NCBI:15444

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