Capn2 - calpain 2 Gene

Rattus norvegicus

Gene ID: 29154 | Gene type: protein coding

About Capn2

Summary

Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cell death; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Colocalizes with mitochondrial intermembrane space. Biomarker of hypertrophic cardiomyopathy and sciatic neuropathy. Orthologous to human CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Apr 2022]

Capn2 Products(1)

mRNA	Protein	Name
NM_017116.2	NP_058812.1	calpain-2 catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	14976200	RGD
contributes to calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	7982961	RGD
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	14976200	RGD
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	17429681	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	20850499	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15476820	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	7982961	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to pain	IDA IDA: Inferred from direct assay	25150005	RGD
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	22711986	RGD
involved in cellular response to interferon-beta	IEP IEP: Inferred from expression pattern	23390485	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	23390485	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	24271063	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21268078	RGD
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	7657725	RGD
involved in positive regulation of phosphatidylcholine biosynthetic process	IMP IMP: Inferred from mutant phenotype	9481489	RGD
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	17182728	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	17402852	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	22711986	RGD
involved in regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	25150005	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	15101113	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15979593	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17182728	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	12404510	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	22711986	RGD
located in dendrite	IDA IDA: Inferred from direct assay	22711986	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9299163	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	24271063	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12404510	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calpain-2 catalytic subunit

CANP 2	M-calpain
calcium-activated neutral proteinase 2	calpain 2, (m/II) large subunit
calpain II	calpain M-type
calpain-2 large subunit	millimolar-calpain

Capn2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Capn2	Q07009	srp-6	Caenorhabditis elegans	G5EFH4	Enzymatic Study	17889653
Intra	Capn2	Q07009	Cast	Rattus norvegicus	P27321	X-Ray Diffraction	19020623
Intra	Capn2	Q07009	Cast	Rattus norvegicus	P27321	X-Ray Diffraction	19020622
Intra	Capn2	Q07009	Cast	Rattus norvegicus	P27321	GMS	19020623
Intra	Capn2	Q07009	Cast	Rattus norvegicus	P27321	NMR	19020622
Intra	Capn2	Q07009	Cast	Rattus norvegicus	P27321	GMS	19020622
Intra	Capn2	Q07009	Cast	Rattus norvegicus	P27321	SPR	17543955
Intra	Capn2	Q07009	Capns1	Rattus norvegicus	Q64537	X-Ray Diffraction	19020622
Intra	Capn2	Q07009	Capns1	Rattus norvegicus	Q64537	GMS	19020623
Intra	Capn2	Q07009	Capns1	Rattus norvegicus	Q64537	GMS	19020622
Intra	Capn2	Q07009	Capns1	Rattus norvegicus	Q64537	X-Ray Diffraction	10601010
Intra	Capn2	Q07009	Capns1	Rattus norvegicus	Q64537	NMR	19020622
Intra	Capn2	Q07009	Capns1	Rattus norvegicus	Q64537	X-Ray Diffraction	19020623

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01889	CAPN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01896	CAPNS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18379	Capn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24859	Capn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Capn2	NCBI	NCBI:824

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