Trpa1 - transient receptor potential cation channel, subfamily A, member 1 Gene

Mus musculus

Also known as Anktm1; TRPA1b

Gene ID: 277328 | Gene type: protein coding

About Trpa1

Summary

Enables Calcium Channel activity. Involved in several processes, including cell surface receptor signaling pathway; cellular calcium ion homeostasis; and response to organic cyclic compound. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to hydrogen peroxide; and thermoception. Located in stereocilium bundle. Is expressed in cochlea and glossopharyngeal ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpa1 Products(2)

mRNA	Protein	Name
NM_001348288.1	NP_001335217.1	transient receptor potential cation channel subfamily A member 1 isoform 2
NM_177781.5	NP_808449.1	transient receptor potential cation channel subfamily A member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	12654248	MGI
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	18398506	MGI
enables channel activity	IDA IDA: Inferred from direct assay	15483558	MGI
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	15843607	MGI
enables monoatomic ion channel activity	IMP IMP: Inferred from mutant phenotype	15483558	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25640077	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	17588549	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	18398506	MGI
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25605129	MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain	IDA IDA: Inferred from direct assay	18272293	MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16564016	MGI
involved in detection of mechanical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	25101983	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16630838	MGI
acts upstream of or within response to cold	IDA IDA: Inferred from direct assay	12654248	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	16630838	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	18398506	MGI
involved in response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	25605129	MGI
acts upstream of or within response to pain	IDA IDA: Inferred from direct assay	18272293	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	16630838	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	18272293	MGI
acts upstream of or within thermoception	IDA IDA: Inferred from direct assay	12654248	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in stereocilium bundle	IDA IDA: Inferred from direct assay	15483558	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily A member 1

ankyrin-like with transmembrane domains protein 1

wasabi receptor

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6810	Thymol		99.97%	Yes
HY-B1173	(+)-Camphor	Inhibitor	≥98.0%	Unkown
HY-N6810R	Thymol (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108463	A-967079	Antagonist	99.30%	Phase 1
HY-115877	GDC-0334	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100965	Diphenyleneiodonium chloride		99.91%	Unkown
HY-15064	HC-030031	Inhibitor	99.49%	Unkown
HY-153169	6PPD-Q	Inhibitor	99.30%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-N6825	Hydroxy-α-sanshool	Agonist	99.57%	Unkown
HY-107436	LE135		≥99.0%	Unkown
HY-111132	JT010	Agonist	99.48%	Unkown
HY-135013	Umbellulone	Activator	99.60%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-18779	PF-4840154	Agonist	98.15%	Unkown
HY-108329	AM-0902	Antagonist	99.73%	Unkown
HY-W014421	AP-18	Inhibitor	99.61%	Unkown
HY-120689	PF-04745637	Antagonist	99.97%	Unkown
HY-101907	ASP7663	Agonist	99.16%	Unkown
HY-121539	Supercinnamaldehyde	Activator	≥99.0%	Unkown
HY-121636	Resolvin D2	Inhibitor	99.90%	Unkown
HY-156684	Nedizantrep	Inhibitor	99.77%	Unkown
HY-12809	Optovin	Activator	99.81%	Unkown
HY-148236	BAY-390	Inhibitor	99.74%	Unkown
HY-N2318	Podocarpic acid	Agonist	99.78%	Unkown
HY-W002116	Methyl syringate		99.96%	Unkown
HY-107535	AS1269574		99.84%	Unkown
HY-134098	Diisopropyl adipate	Activator	99.90%	Unkown
HY-15065	Chembridge-5861528	Antagonist	99.76%	Unkown
HY-153711	TRPA1-IN-2	Inhibitor	99.82%	Unkown
HY-N7117	1,4-Cineole	Activator	≥95.0%	Unkown
HY-P5914A	Wasabi Receptor Toxin TFA	Activator	99.49%	Unkown
HY-114524	(E)-4-Oxo-2-nonenal	Agonist	≥95.0%	Unkown
HY-N10319	Artepillin C		95.91%	Unkown
HY-121636S	Resolvin D2-d5	Inhibitor	≥99.0%	Unkown
HY-N7536	Voacangine		98.78%	Unkown
HY-P5914	Wasabi Receptor Toxin	Activator	/	Unkown
HY-W008356	2-Fluoro-4-iodobenzonitrile		/	Unkown
HY-W106234	4-(Phenyldiazenyl)benzoic acid	Agonist	98.81%	Unkown
HY-142214	TRPA1-IN-1	Antagonist	/	Unkown
HY-111494	TRPA1 Antagonist 1	Inhibitor	/	Unkown
HY-104061	AMG8788	Antagonist	/	Unkown
HY-104062	AMG9678	Antagonist	/	Unkown
HY-139904	TRPA1 Antagonist 3	Agonist	/	Unkown
HY-15056	AMG 9090	Agonist	/	Unkown
HY-170652	ZQMT-10	Inhibitor	/	Unkown
HY-172898	TRPA1-IN-4	Inhibitor	/	Unkown
HY-173471	TRPA1 agonist-1	Agonist	/	Unkown
HY-N12605	hTRPA1-IN-1	Inhibitor	/	Unkown
HY-N7965	Methyl kakuol	Agonist	/	Unkown
HY-P10356	T100-Mut	Inhibitor	/	Unkown
HY-RS15103	TRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W002116S	Methyl syringate-d6		/	Unkown
HY-W010270A	Aurothiomalate disodium		/	Unkown
HY-113018	Ibuprofen acyl-β-D-glucuronide	Antagonist	/	Unkown
HY-159134	TRPA1-IN-3	Inhibitor	/	Unkown
HY-N10612	Petasin		/	Unkown
HY-RS16515	Trpa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22946	Trpa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W708469	Resolvin D2 methyl ester	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpa1	NCBI	NCBI:8989

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