Nlrc4 - NLR family, CARD domain containing 4 Gene

Mus musculus

Also known as CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; Card12; 9530011P19Rik

Gene ID: 268973 | Gene type: protein coding

About Nlrc4

Summary

Enables identical protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; protein homooligomerization; and response to bacterium. Acts upstream of or within regulation of apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol. Part of IPAF inflammasome complex. Used to study familial cold autoinflammatory syndrome 4. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc4 Products(1)

mRNA	Protein	Name
NM_001033367.3	NP_001028539.1	NLR family CARD domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26449474	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22885697	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	16648852	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	16648852	MGI
involved in detection of bacterium	IMP IMP: Inferred from mutant phenotype	22885697	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	15190255	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	16648852	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16648852	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	21874021	MGI
involved in pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	16648852	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15190255	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15190255	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of IPAF inflammasome complex	IDA IDA: Inferred from direct assay	21874021	MGI
located in cytosol	IDA IDA: Inferred from direct assay	22885697	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NLR family CARD domain-containing protein 4

caspase recruitment domain family, member 12	caspase recruitment domain-containing protein 12
ice protease-activating factor

Nlrc4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nlrc4	Q3UP24	Naip5	Mus musculus	Q9R016	Pull Down	26449474
Intra	Nlrc4	Q3UP24	Naip5	Mus musculus	Q9R016	Anti Tag CoIP	26449474
Intra	Nlrc4	Q3UP24	Naip5	Mus musculus	Q9R016	GMS	23765277
Intra	Nlrc4	Q3UP24	Casp1	Mus musculus	P29452	Anti Tag CoIP	22885697
Intra	Nlrc4	Q3UP24	Casp1	Mus musculus	P29452	FPS	26449474

Cross: Cross-species interaction Intra: Intraspecies interaction

Nlrc4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84624	phospho-NLRC4(Ser-533) Antibody (YA4321)	WB, ICC/IF, ELISA	Human, Mouse
HY-P84625	phospho-NLRC4(Ser-533) Antibody (YA4322)	ICC/IF, FC, ELISA	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152670	JC2-11	Inhibitor	98.03%	Unkown
HY-148258	GDC-2394	Inhibitor	99.54%	Unkown
HY-161669	NLRP3-IN-40	Inhibitor	/	Unkown
HY-170233	NLRP3-IN-75	Inhibitor	/	Unkown
HY-RS09347	NLRC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17988	Nlrc4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24459	Nlrc4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrc4	NCBI	NCBI:58484

Name
Email *

	Sorry, but the email address you supplied was invalid.