Nlrc3 - NLR family, CARD domain containing 3 Gene

Mus musculus

Also known as CLR16.2; mFLJ00348; D230007K08Rik

Gene ID: 268857 | Gene type: protein coding

About Nlrc3

Summary

Enables phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of cytokine production; and negative regulation of defense response. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein ubiquitination; and response to lipopolysaccharide. Predicted to be located in centriolar satellite; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human NLRC3 (NLR family CARD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc3 Products(2)

mRNA	Protein	Name
NM_001081280.2	NP_001074749.1	protein NLRC3 isoform 1
NM_175547.4	NP_780756.1	protein NLRC3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	22863753	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	27951586	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22863753	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22863753	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	22863753	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	22863753	MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22863753	MGI
involved in negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	24560620	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	27951586	MGI
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	27951586	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24560620	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	24560620	MGI
involved in negative regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	24560620	MGI
involved in negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	24560620	MGI
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	22863753	MGI
involved in negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	22863753	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22863753	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	27951586	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	22863753	MGI
acts upstream of or within regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	22863753	MGI
acts upstream of or within regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22863753	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	22863753	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein NLRC3

caterpillar 16.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0921	Dihydromethysticin		99.94%	Unkown
HY-RS09346	NLRC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20066	Nlrc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26570	Nlrc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrc3	NCBI	NCBI:197358

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