Ahr - aryl hydrocarbon receptor Gene

Rattus norvegicus

Gene ID: 25690 | Gene type: protein coding

About Ahr

Summary

Enables nuclear receptor activity and toxic substance binding activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of Alkaline Phosphatase activity; and regulation of cellular macromolecule biosynthetic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (Aryl Hydrocarbon Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ahr Products(3)

mRNA	Protein	Name
NM_001308254.1	NP_001295183.1	aryl hydrocarbon receptor isoform 2
NM_001308255.1	NP_001295184.1	aryl hydrocarbon receptor isoform 3
NM_013149.3	NP_037281.3	aryl hydrocarbon receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate omega-hydroxylase activity	IMP IMP: Inferred from mutant phenotype	19889059	RGD
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	7812217	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11259609	RGD
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	9056263	RGD
enables sequence-specific double-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	15492120	RGD
enables toxic substance binding	IDA IDA: Inferred from direct assay	18938125	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in aflatoxin metabolic process	IEP IEP: Inferred from expression pattern	28959666	RGD
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IDA IDA: Inferred from direct assay	9658193	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	9804617	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	17690134	RGD
involved in cellular response to toxic substance	IMP IMP: Inferred from mutant phenotype	31746392	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	9813174	RGD
involved in conditioned taste aversion	IMP IMP: Inferred from mutant phenotype	30769105	RGD
involved in contact inhibition	IMP IMP: Inferred from mutant phenotype	17952121	RGD
involved in estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	26372666	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21666223	RGD
involved in mammary duct terminal end bud growth	IDA IDA: Inferred from direct assay	26372666	RGD
involved in negative regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	12193573	RGD
involved in negative regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	17952121	RGD
involved in negative regulation of alkaline phosphatase activity	IDA IDA: Inferred from direct assay	12193573	RGD
involved in negative regulation of calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	12193573	RGD
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17952121	RGD
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	12193573	RGD
involved in negative regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	12193573	RGD
involved in nitric oxide metabolic process	IEP IEP: Inferred from expression pattern	31489946	RGD
involved in omega-hydroxylase P450 pathway	IMP IMP: Inferred from mutant phenotype	19889059	RGD
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	20466593	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	32913241	RGD
involved in positive regulation of mating-type specific transcription, DNA-templated	IDA IDA: Inferred from direct assay	9056263	RGD
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	32913241	RGD
involved in reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	35788946	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7812217	RGD
involved in regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	33766215	RGD
involved in regulation of eating behavior	IDA IDA: Inferred from direct assay	27594096	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	23999541	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	20176079	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18059014	RGD
involved in response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	20403408	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	9653054	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9658193	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10053172	RGD
involved in tissue remodeling	IEP IEP: Inferred from expression pattern	23887904	RGD
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7812217	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18515748	RGD
located in nucleus	IDA IDA: Inferred from direct assay	7812217	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor

ah receptor

Related Agents

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109044	Tapinarof	Agonist	99.95%	Unkown
HY-N0178	Diosmin	Agonist	99.51%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-B0311	Carbidopa	Modulator	≥98.0%	Yes
HY-B0678	Metaxalone		99.77%	Unkown
HY-17357	Nepafenac	Inhibitor	99.56%	Unkown
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes
HY-B0311A	Carbidopa monohydrate	Modulator	≥98.0%	Yes
HY-17479	Amfenac		/	Unkown
HY-A0083B	Methacholine bromide	Agonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B2132	Tryptamine		99.77%	Phase 3
HY-15001	Stemregenin 1	Antagonist	99.95%	Phase 2
HY-N0170	Indole-3-carbinol		98.87%	Phase 2
HY-16031	AFP464 free base	Inhibitor	/	Phase 2
HY-111449	BAY-218	Antagonist	99.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (131)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12028	PD98059		99.96%	Unkown
HY-12684	CH-223191	Antagonist	99.96%	Unkown
HY-15484	Pifithrin-α hydrobromide		98.58%	Unkown
HY-12451	FICZ	Agonist	99.42%	Unkown
HY-W028393	Indole-3-pyruvic acid	Agonist	99.79%	Unkown
HY-135829	BAY 2416964	Antagonist	99.59%	Unkown
HY-19317	ITE	Agonist	99.27%	Unkown
HY-W007355	Skatole		99.97%	Unkown
HY-102023	GNF351	Antagonist	99.87%	Unkown
HY-W015273A	trans-3-Indoleacrylic acid	Inhibitor	99.39%	Unkown
HY-103220	6,2',4'-Trimethoxyflavone	Antagonist	98.09%	Unkown
HY-122208	SGA360	Inhibitor	99.93%	Unkown
HY-W011338	Benzyl butyl phthalate	Activator	≥97.0%	Unkown
HY-114740	β-Naphthoflavone		99.95%	Unkown
HY-135750	VAF347	Agonist	99.90%	Unkown
HY-134217	KYN-101	Inhibitor	98.17%	Unkown
HY-W014502	D-Kynurenine	Agonist	99.67%	Unkown
HY-103221	MeBIO		≥98.0%	Unkown
HY-112629	PDM2	Antagonist	98.76%	Unkown
HY-119019	ASB14780	Inhibitor	99.83%	Unkown
HY-144339	AhR agonist 2		99.89%	Unkown
HY-18619	YL-109	Modulator	99.26%	Unkown
HY-141609	IK-175	Inhibitor	99.56%	Unkown
HY-W014075	1-Hydroxypyrene		99.84%	Unkown
HY-B0845	Prochloraz		99.77%	Unkown
HY-112628	CAY10464	Antagonist	99.77%	Unkown
HY-112627	CAY 10465	Agonist	98.30%	Unkown
HY-135831	AHR antagonist 2	Antagonist	99.91%	Unkown
HY-15001G	Stemregenin 1 (GMP)	Antagonist	/	Unkown
HY-N0914	Ajugol		99.13%	Unkown
HY-118438	10-Cl-BBQ	Agonist	99.48%	Unkown
HY-130256	β-NF-JQ1	Inhibitor	99.37%	Unkown
HY-117532	PenCB	Inducer	99.94%	Unkown
HY-124421	5F-203	Inducer	99.04%	Unkown
HY-12545	Brevetoxin-3	Activator	95.0%	Unkown
HY-D0932	Sudan IV		≥98.0%	Unkown
HY-N4095	Brevifolincarboxylic acid	Inhibitor	99.90%	Unkown
HY-105791	Sulazepam		99.56%	Unkown
HY-111450	CB7993113	Antagonist	≥98.0%	Unkown
HY-N0586	Norisoboldine	Agonist	/	Unkown
HY-W014701	1,4-Dihydroxy-2-naphthoic acid	Activator	99.60%	Unkown
HY-77278	25-Hydroxytachysterol3	Agonist	98.89%	Unkown
HY-100242	Mivotilate	Activator	99.58%	Unkown
HY-103223	Phortress	Inducer	99.25%	Unkown
HY-114682	Lenperone	Antagonist	98.11%	Unkown
HY-117102	ANI-7	Activator	98.13%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-17357S	Nepafenac-d5	Inhibitor	98.84%	Unkown
HY-N6264	26-Deoxyactein	Inhibitor	99.76%	Unkown
HY-W718300	Indole-3-pyruvic acid-d5		95.00%	Unkown
HY-111441	1,4-Chrysenequinone	Activator	98.42%	Unkown
HY-118474	GW 610	Activator	99.78%	Unkown
HY-118780	CHD-5	Antagonist	≥98.0%	Unkown
HY-16031B	AFP464 dihydrochloride	Inhibitor	99.67%	Unkown
HY-N0586A	Norisoboldine hydrochloride	Agonist	99.72%	Unkown
HY-N10123	Indolokine A5	Agonist	≥98.0%	Unkown
HY-RS00483	AHR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W014075S	1-Hydroxypyrene-d9		99.95%	Unkown
HY-136220	AHR antagonist 5	Antagonist	98.05%	Unkown
HY-104026CS	L-Kynurenine-13C10 sulfate hemihydrate	Agonist	99.90%	Unkown
HY-W011338S	Benzyl butyl phthalate-d4		/	Unkown
HY-W046846	Corannulene	Agonist	≥97.0%	Unkown
HY-154825	20-Hydroxyvitamin D3		≥98.0%	Unkown
HY-B0973	Dibenzothiophene	Inhibitor	99.88%	Unkown
HY-N10295	Flavipin	Agonist	/	Unkown
HY-W764758	3-OH-Kynurenamine dihydroiodide	Activator	99.56%	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-136220A	AHR antagonist 5 hemimaleate	Antagonist	/	Unkown
HY-101802	Fluzinamide		/	Unkown
HY-103222	DiMNF	Modulator	98.01%	Unkown
HY-104026B	L-Kynurenine sulfate	Agonist	/	Unkown
HY-106487	Pridefine	Inhibitor	/	Unkown
HY-111157	Dezinamide		/	Unkown
HY-114682A	Lenperone hydrochloride	Antagonist	/	Unkown
HY-116148	AHR-11797		/	Unkown
HY-116638	AHR-5333	Inhibitor	/	Unkown
HY-116638A	AHR-5333 (mandelate)	Inhibitor	/	Unkown
HY-117774	AHR-2244 hydrochloride		/	Unkown
HY-118792	AHR activator 1		/	Unkown
HY-119018	AHR-6293	Inhibitor	/	Unkown
HY-119960	AHR-10037	Inhibitor	/	Unkown
HY-120377	CYP1A1 inhibitor 8a	Inhibitor	/	Unkown
HY-120677	AHR-15010	Inhibitor	/	Unkown
HY-123432	AHR-13268D	Inhibitor	/	Unkown
HY-123461	Sul-121 hydrochloride	Inhibitor	/	Unkown
HY-124021	Benzyl 2-naphthyl ether		/	Unkown
HY-125926S	2-Ketodoxapram-d5		/	Unkown
HY-129305	Tampramine fumarate	Inhibitor	/	Unkown
HY-130269	β-Naphthoflavone-CH2-OH		/	Unkown
HY-130270	AhR Ligand-Linker Conjugates 1		/	Unkown
HY-130842	β-Naphthoflavone-CH2-Br		/	Unkown
HY-135671	AhR modulator-1		/	Unkown
HY-135830	AHR antagonist 4	Antagonist	/	Unkown
HY-136891	AHR-16303B		/	Unkown
HY-139117	6,2′,4′-Trimethoxyflavone	Antagonist	/	Unkown
HY-155505	AHR agonist 4	Agonist	/	Unkown
HY-156908	3-OH-Kynurenamine	Activator	/	Unkown
HY-158167	AhR agonist 5	Agonist	/	Unkown
HY-158168	AhR agonist 6	Agonist	/	Unkown
HY-158169	AhR agonist 7	Agonist	/	Unkown
HY-161649	hCYP1B1-IN-2	Inhibitor	/	Unkown
HY-168033	AhR agonist 8	Agonist	/	Unkown
HY-169753	AHR-IN-1	Inhibitor	/	Unkown
HY-17479B	Amfenac sodium		/	Unkown
HY-19826	Isofistularin-3		/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-B0311AS	Carbidopa-d3 monohydrate	Modulator	≥98.0%	Unkown
HY-B0311D	Carbidopa hydrochloride	Modulator	/	Unkown
HY-B0311S1	Carbidopa-d3-1	Modulator	/	Unkown
HY-B0678S	Metaxalone-d3		≥98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-B0973S	Dibenzothiophene-d8	Inhibitor	/	Unkown
HY-N12537A	(2R,3S)-PD-1/PD-L1-IN-38		/	Unkown
HY-W014502R	D-Kynurenine (Standard)	Agonist	/	Unkown
HY-W338764	AHR agonist 3		99.79%	Unkown
HY-W517076	1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin	Agonist	/	Unkown
HY-101745	Rocastine	Antagonist	/	Unkown
HY-104026BS	L-Kynurenine-13C10 sulfate	Agonist	/	Unkown
HY-107063	AHR-1911	Activator	/	Unkown
HY-109044S	Tapinarof-d5	Agonist	/	Unkown
HY-118910	AHR-14310C	Antagonist	/	Unkown
HY-119991	AHR-9294	Inhibitor	/	Unkown
HY-125926S1	2-Ketodoxapram-d4		/	Unkown
HY-128229	AHR antagonist 6	Antagonist	/	Unkown
HY-130456	AHR 10718	Inhibitor	/	Unkown
HY-163665	AHR antagonist 8		/	Unkown
HY-170514	1,2,3,7,8,9-Hexachlorodibenzofuran	Ligand	/	Unkown
HY-D0932S	Sudan IV-d6		/	Unkown
HY-RS16533	Ahr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22964	Ahr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-U00010	Dazopride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ahr	NCBI	NCBI:196

Name
Email *

	Sorry, but the email address you supplied was invalid.