2. Gene
  3. Cyp24a1 - cytochrome P450, family 24, subfamily a, polypeptide 1 Gene

Cyp24a1 - cytochrome P450, family 24, subfamily a, polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cyp24; VITD12; 24-OHase; 24R-Ohase; P450-CC24

Gene ID: 25279 | Gene type: protein coding

About Cyp24a1

Summary

Enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; and vitamin D 25-hydroxylase activity. Involved in vitamin D catabolic process. Predicted to be located in mitochondrion and nucleoplasm. Human ortholog(s) of this gene implicated in hypercalcemia. Orthologous to human CYP24A1 (Cytochrome P450 family 24 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp24a1 Products(1)

mRNA Protein Name
NM_201635.3 NP_963966.1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity IDA
IDA: Inferred from direct assay
10231362 RGD
enables 25-hydroxycholecalciferol-24-hydroxylase activity IDA
IDA: Inferred from direct assay
1991512 RGD
enables vitamin D 24-hydroxylase activity IDA
IDA: Inferred from direct assay
25727742 RGD
enables vitamin D 25-hydroxylase activity IDA
IDA: Inferred from direct assay
25727742 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
28104492 RGD
involved in vitamin D catabolic process IDA
IDA: Inferred from direct assay
10231362 RGD
involved in vitamin D metabolic process IDA
IDA: Inferred from direct assay
1991512 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

25-hydroxyvitamin D3 24-hydroxylase

25-hydroxyvitaminD324-hydroxylase

Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)

cytochrome P450 24A1

cytochrome P450, subfamily 24

cytochrome P450-CC24

vitamin D(3) 24-hydroxylase

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0105 Ketoconazole Inhibitor 99.51% Yes
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-77278 25-Hydroxytachysterol3 Agonist 98.89% Unkown
HY-B0105S1 Ketoconazole-d4 Inhibitor 99.63% Unkown
HY-B0105S Ketoconazole-d8 Inhibitor 99.79% Unkown
HY-RS03446 CYP24A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-166670S Ketoconazole carbonyl-13C Inhibitor / Unkown
HY-RS19541 Cyp24a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26037 Cyp24a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp24a1 NCBI NCBI:1591