2. Gene
  3. Gpc3 - glypican 3 Gene

Gpc3 - glypican 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as OCI-5

Gene ID: 25236 | Gene type: protein coding

About Gpc3

Summary

Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Is anchored component of plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Apr 2022]

Gpc3 Products(1)

mRNA Protein Name
NM_012774.2 NP_036906.2 glypican-3 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
15537637 RGD
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
IDA: Inferred from direct assay
15537637 RGD
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
15537637 RGD
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
7487896 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glypican-3

defective in Simpson-Golabi-Behmel overgrowth syndrome

intestinal protein OCI-5

proteoglycan GPC3

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99013 Codrituzumab Inhibitor 99.07% Phase 2
HY-P991216 ERY-974 / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153360 MC-GGFG-AM-(10Me-11F-Camptothecin) Inhibitor 98.99% Unkown
HY-RS05628 GPC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-P10888 GPC3 targeting peptide 1 / Unkown
HY-RS16630 Gpc3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23065 Gpc3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990840 Anti-GPC3 Antibody (YP7) Inhibitor ≥95.0% Unkown
HY-P991448 MDX-1414 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpc3 NCBI NCBI:2719
Macaca fascicularis Gpc3 NCBI NCBI:102137748
Mus musculus Gpc3 NCBI NCBI:14734