Cnksr2 - connector enhancer of kinase suppressor of Ras 2 Gene

Mus musculus

Also known as Cnk2; Ksr2

Gene ID: 245684 | Gene type: protein coding

About Cnksr2

Summary

Predicted to enable identical protein binding activity and protein kinase binding activity. Predicted to be involved in postsynapse organization. Predicted to act upstream of or within intracellular signal transduction. Located in postsynaptic density. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnksr2 Products(3)

mRNA	Protein	Name
NM_001310719.1	NP_001297648.1	connector enhancer of kinase suppressor of ras 2 isoform 2
NM_001374835.1	NP_001361764.1	connector enhancer of kinase suppressor of ras 2 isoform 3
NM_177751.3	NP_808419.1	connector enhancer of kinase suppressor of ras 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28671696	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in postsynaptic specialization organization	IDA IDA: Inferred from direct assay	36803960	MGI
involved in postsynaptic specialization organization	IMP IMP: Inferred from mutant phenotype	36803960	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	36803960	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	36803960	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

connector enhancer of kinase suppressor of ras 2

CNK homolog protein 2	connector enhancer of KSR 2
connector enhancer of KSR2

Cnksr2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cnksr2	Q80YA9	Dlgap1	Mus musculus	Q9D415	Anti Bait CoIP	28671696

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02889	CNKSR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnksr2	NCBI	NCBI:22866

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