Tspo - translocator protein Gene

Rattus norvegicus

Also known as MBR; Bzrp; Ptbzr; PTBZR02; RATPTBZR02

Gene ID: 24230 | Gene type: protein coding

About Tspo

Summary

Enables androgen binding activity and benzodiazepine receptor activity. Involved in several processes, including cellular response to zinc ion; neurogenesis; and positive regulation of cell death. Located in mitochondrial outer membrane. Used to study Cholesterol ester storage disease. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]

Tspo Products(1)

mRNA	Protein	Name
NM_012515.2	NP_036647.1	translocator protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables androgen binding	IDA IDA: Inferred from direct assay	8918981	RGD
enables benzodiazepine receptor activity	IDA IDA: Inferred from direct assay	2555358	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17174393	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	9927316	RGD
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	19555675	RGD
involved in cellular hypotonic response	IEP IEP: Inferred from expression pattern	18709649	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	14678758	RGD
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	18709649	RGD
involved in chloride transport	IDA IDA: Inferred from direct assay	14726306	RGD
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	29074640	RGD
involved in contact inhibition	IDA IDA: Inferred from direct assay	18190798	RGD
involved in glial cell migration	IDA IDA: Inferred from direct assay	18190798	RGD
involved in monoatomic ion transport	IDA IDA: Inferred from direct assay	14726306	RGD
involved in negative regulation of corticosterone secretion	IMP IMP: Inferred from mutant phenotype	29074640	RGD
involved in negative regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	14678758	RGD
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	14678758	RGD
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	14678758	RGD
involved in peripheral nervous system axon regeneration	IEP IEP: Inferred from expression pattern	8977149	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15284300	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	17174393	RGD
involved in positive regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	18190798	RGD
involved in positive regulation of mitochondrial depolarization	IDA IDA: Inferred from direct assay	15183124	RGD
involved in positive regulation of programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	15284300	RGD
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	12437594	RGD
involved in regulation of steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	9974124	RGD
involved in response to acetylcholine	IMP IMP: Inferred from mutant phenotype	29074640	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	15255978	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	12946575	RGD
involved in response to pain	IEP IEP: Inferred from expression pattern	19555675	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	8201845	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	8201845	RGD
involved in response to vitamin B1	IEP IEP: Inferred from expression pattern	10517697	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17561380	RGD
involved in steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	9405411	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	19863077	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

translocator protein

Benzodiazepin receptor (peripheral)	PBR
PKBS	benzodiazepine receptor, peripheral
mitochondrial benzodiazepine receptor	peripheral-type benzodiazepine receptor

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15527	Emapunil	Inhibitor	99.94%	Phase 2
HY-111191	ONO-2952		99.51%	Phase 2
HY-122607	DPA-714		99.86%	Phase 2
HY-141804	ER176		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19567	PK 11195	Inhibitor	≥99.0%	Unkown
HY-148833	MDM2-p53-IN-16	Inhibitor	99.08%	Unkown
HY-150407	TSPO ligand-1	Inducer	≥98.0%	Unkown
HY-153248	PBR28		99.44%	Unkown
HY-400882	Tosylate-DPA-714		97.01%	Unkown
HY-111191A	(R)-ONO-2952		99.97%	Unkown
HY-150409	TSPO ligand-2		99.63%	Unkown
HY-169964	TSPO/Carbonic Anhydrase Modulator 1	Modulator	/	Unkown
HY-147225	TSPO Ligand-Linker Conjugates 1	Activator	/	Unkown
HY-150410	TSPO ligand-3		/	Unkown
HY-172534	BPN-01	Substrate	/	Unkown
HY-RS15177	TSPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15178	TSPO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W634748	Desalkylgidazepam	Agonist	/	Unkown
HY-RS16721	Tspo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23157	Tspo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W782122	Photoclick cholesterol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tspo	NCBI	NCBI:706
Mus musculus	Tspo	NCBI	NCBI:12257

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