Tspo - translocator protein Gene

Mus musculus

Also known as IBP; PBR; Bzrp; Tspo1

Gene ID: 12257 | Gene type: protein coding

About Tspo

Summary

Enables transmembrane transporter binding activity. Involved in several processes, including negative regulation of Autophagy of mitochondrion; negative regulation of protein ubiquitination; and protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]

Tspo Products(1)

mRNA	Protein	Name
NM_009775.4	NP_033905.3	translocator protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	25470454	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	25470454	MGI
involved in maintenance of protein location in mitochondrion	IMP IMP: Inferred from mutant phenotype	25470454	MGI
involved in negative regulation of ATP metabolic process	IMP IMP: Inferred from mutant phenotype	25470454	MGI
involved in negative regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	25470454	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	25470454	MGI
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	25470454	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	25470454	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

translocator protein

PKBS	benzodiazepine receptor, peripheral
isoquinoline-binding protein	mitochondrial benzodiazepine receptor
peripheral-type benzodiazepine receptor

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15527	Emapunil	Inhibitor	99.94%	Phase 2
HY-111191	ONO-2952		99.51%	Phase 2
HY-122607	DPA-714		99.86%	Phase 2
HY-141804	ER176		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19567	PK 11195	Inhibitor	≥99.0%	Unkown
HY-148833	MDM2-p53-IN-16	Inhibitor	99.11%	Unkown
HY-150407	TSPO ligand-1	Inducer	≥98.0%	Unkown
HY-153248	PBR28		99.44%	Unkown
HY-400882	Tosylate-DPA-714		97.01%	Unkown
HY-150409	TSPO ligand-2		99.63%	Unkown
HY-169964	TSPO/Carbonic Anhydrase Modulator 1	Modulator	/	Unkown
HY-111191A	(R)-ONO-2952		99.97%	Unkown
HY-147225	TSPO Ligand-Linker Conjugates 1	Activator	/	Unkown
HY-150410	TSPO ligand-3		/	Unkown
HY-RS15177	TSPO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15178	TSPO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W634748	Desalkylgidazepam	Agonist	/	Unkown
HY-RS16721	Tspo Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23157	Tspo Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W782122	Photoclick cholesterol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tspo	NCBI	NCBI:706

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