Osr1 - odd-skipped related transcription factor 1 Gene

Mus musculus

Also known as Osr; Odd1

Gene ID: 23967 | Gene type: protein coding

About Osr1

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; cellular response to retinoic acid; and intermediate mesoderm development. Predicted to be located in cytosol. Predicted to be extrinsic component of membrane. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Osr1 Products(1)

mRNA	Protein	Name
NM_011859.3	NP_035989.1	protein odd-skipped-related 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24598167	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell differentiation	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in cell proliferation involved in kidney development	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	20171952	MGI
involved in chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic skeletal joint development	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic skeletal joint morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in embryonic skeletal limb joint morphogenesis	IGI IGI: Inferred from genetic interaction	21262216	MGI
acts upstream of or within gonad development	IMP IMP: Inferred from mutant phenotype	16223478	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16223478	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	16223478	MGI
acts upstream of or within intermediate mesoderm development	IMP IMP: Inferred from mutant phenotype	16223478	MGI
involved in mesangial cell development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in mesonephric duct morphogenesis	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in mesonephros development	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in metanephric cap mesenchymal cell proliferation involved in metanephros development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in metanephric epithelium development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in metanephric glomerulus vasculature development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in metanephric interstitial fibroblast development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in metanephric mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in metanephric mesenchyme development	IDA IDA: Inferred from direct assay	20171952	MGI
involved in metanephric mesenchyme morphogenesis	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in metanephric nephron tubule development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in metanephric smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	16223478	MGI
involved in middle ear morphogenesis	IGI IGI: Inferred from genetic interaction	19389375	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in negative regulation of nephron tubule epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in odontogenesis	IGI IGI: Inferred from genetic interaction	19389375	MGI
involved in pattern specification involved in metanephros development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in positive regulation of bone mineralization	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	19389375	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17547533	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21262216	MGI
involved in posterior mesonephric tubule development	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in renal vesicle progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in roof of mouth development	IGI IGI: Inferred from genetic interaction	19389375	MGI
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	31736353	MGI
involved in specification of anterior mesonephric tubule identity	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in specification of posterior mesonephric tubule identity	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in stem cell differentiation	IDA IDA: Inferred from direct assay	20171952	MGI
involved in ureter urothelium development	IMP IMP: Inferred from mutant phenotype	18835385	MGI
involved in ureteric bud development	IMP IMP: Inferred from mutant phenotype	16790474	MGI
involved in urogenital system development	IMP IMP: Inferred from mutant phenotype	16223478	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein odd-skipped-related 1

odd-skipped related 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151545	WNK1-IN-1	Inhibitor	99.40%	Unkown
HY-RS09852	OSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18147	Osr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24622	Osr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Osr1	NCBI	NCBI:130497

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