Alms1 - ALMS1, centrosome and basal body associated Gene

Mus musculus

Also known as bbb

Gene ID: 236266 | Gene type: protein coding

About Alms1

Summary

Enables alpha-actinin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including Cholesterol homeostasis; gamete generation; and neuron development. Predicted to be active in centriole; centrosome; and cytosol. Is expressed in several structures, including aorta; central nervous system; genitourinary system; gut; and sensory organ. Used to study Alstrom syndrome and obesity. Human ortholog(s) of this gene implicated in Alstrom syndrome. Orthologous to human ALMS1 (ALMS1 centrosome and basal body associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Alms1 Products(1)

mRNA	Protein	Name
NM_145223.2	NP_660258.2	centrosome-associated protein ALMS1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-actinin binding	IPI IPI: Inferred from physical interaction	22693585	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22693585	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of or within calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of or within establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	21071598	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16000322	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	21071598	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	16000322	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17206865	MGI
acts upstream of or within negative regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16513793	MGI
acts upstream of or within ovulation	IMP IMP: Inferred from mutant phenotype	16513793	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27803297	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	16000322	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	31302159	MGI
acts upstream of or within retinal rod cell development	IMP IMP: Inferred from mutant phenotype	16000322	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16000322	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	16513793	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

centrosome-associated protein ALMS1

Alstrom syndrome protein 1 homolog

Alstrom syndrome 1 homolog

alstrom syndrome protein 1 homolog

Alms1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Alms1	Q8K4E0	Actn4	Mus musculus	P57780	Y2H	22693585
Intra	Alms1	Q8K4E0	Actn4	Mus musculus	P57780	Anti Bait CoIP	22693585
Intra	Alms1	Q8K4E0	Actn1	Mus musculus	Q7TPR4	Y2H	22693585
Intra	Alms1	Q8K4E0	Exosc8	Mus musculus	Q9D753	Y2H	22693585

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00611	ALMS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22387	Alms1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28911	Alms1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alms1	NCBI	NCBI:7840

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