Plcg2 - phospholipase C, gamma 2 Gene

Mus musculus

Also known as Plcg-2; PLCgamma2; PLC-gamma-2

Gene ID: 234779 | Gene type: protein coding

About Plcg2

Summary

Enables phosphatidylinositol Phospholipase C activity and phosphorylation-dependent protein binding activity. Involved in several processes, including immune response-regulating signaling pathway; positive regulation of cytokine production; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including activation of store-operated Calcium Channel activity; follicular B cell differentiation; and regulation of calcium-mediated signaling. Located in cytosol. Is expressed in several structures, including alimentary system; bone; cardiovascular system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (Phospholipase C gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Plcg2 Products(1)

mRNA	Protein	Name
NM_172285.2	NP_758489.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol phospholipase C activity	EXP EXP: Inferred from Experiment	8615781	MGI
enables phosphorylation-dependent protein binding	IPI IPI: Inferred from physical interaction	10744659	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8395016	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	10925250	MGI
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10925250	MGI
acts upstream of or within T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	15728238	MGI
acts upstream of or within activation of store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	15611229	MGI
involved in antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	22041900	MGI
involved in cell activation	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in cellular response to lectin	IMP IMP: Inferred from mutant phenotype	19136564	MGI
acts upstream of or within follicular B cell differentiation	IMP IMP: Inferred from mutant phenotype	12928432	MGI
acts upstream of or within inositol trisphosphate biosynthetic process	IDA IDA: Inferred from direct assay	9013981	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	22041900	MGI
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	12928432	MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of I-kappaB phosphorylation	IMP IMP: Inferred from mutant phenotype	22041900	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	19136564	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of dendritic cell cytokine production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	22041900	MGI
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-23 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
acts upstream of positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	22041900	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	22041900	MGI
acts upstream of positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	22041900	MGI
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	22078883	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	22078883	MGI
acts upstream of programmed cell death	IMP IMP: Inferred from mutant phenotype	12928432	MGI
acts upstream of or within regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19136564	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12928432	MGI
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	10925250	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	9013981	MGI
involved in response to yeast	IMP IMP: Inferred from mutant phenotype	22041900	MGI
involved in stimulatory C-type lectin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19136564	MGI
involved in toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19136564	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IMP IMP: Inferred from mutant phenotype	10925250	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	23478294	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

phosphoinositide phospholipase C-gamma-2

Plcg2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Plcg2	Q8CIH5	Fhl2	Mus musculus	O70433	Y2H	15102471
Intra	Plcg2	Q8CIH5	Inpp5d	Mus musculus	Q9ES52	Y2H	15102471
Intra	Plcg2	Q8CIH5	Pdcd6ip	Mus musculus	Q9WU78	Y2H	15102471
Intra	Plcg2	Q8CIH5	Fn1	Mus musculus	P11276	Y2H	15102471
Intra	Plcg2	Q8CIH5	Flna	Mus musculus	Q8BTM8	Y2H	15102471
Intra	Plcg2	Q8CIH5	Trim27	Mus musculus	Q62158	Y2H	15102471
Intra	Plcg2	Q8CIH5	Zbtb7b	Mus musculus	Q64321	Y2H	15102471
Intra	Plcg2	Q8CIH5	Lyn	Mus musculus	P25911	Pull Down	8395016

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10661	PLCG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19471	Plcg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25964	Plcg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plcg2	NCBI	NCBI:5336

Name
Email *

	Sorry, but the email address you supplied was invalid.