Zbtb7b - zinc finger and BTB domain containing 7B Gene

Mus musculus

Also known as Thpok; Zfp67; c-Krox

Gene ID: 22724 | Gene type: protein coding

About Zbtb7b

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of alpha-beta T cell activation. Acts upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; sensory organ; and skin. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb7b Products(8)

mRNA	Protein	Name
NM_001355206.2	NP_001342135.2	zinc finger and BTB domain-containing protein 7B
NM_001355211.2	NP_001342140.1	zinc finger and BTB domain-containing protein 7B
NM_001355212.2	NP_001342141.1	zinc finger and BTB domain-containing protein 7B
NM_001410678.1	NP_001397607.1	zinc finger and BTB domain-containing protein 7B
NM_001410679.1	NP_001397608.1	zinc finger and BTB domain-containing protein 7B
NM_001410680.1	NP_001397609.1	zinc finger and BTB domain-containing protein 7B
NM_001410681.1	NP_001397610.1	zinc finger and BTB domain-containing protein 7B
NM_009565.6	NP_033591.2	zinc finger and BTB domain-containing protein 7B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7937772	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7937772	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8702912	MGI
enables DNA-binding transcription repressor activity	IMP IMP: Inferred from mutant phenotype	22730529	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7937772	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8702912	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	22730529	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	8702912	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	22730529	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in NK T cell differentiation	IMP IMP: Inferred from mutant phenotype	23105140	MGI
involved in adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	28784777	MGI
involved in lactation	IMP IMP: Inferred from mutant phenotype	29420538	MGI
involved in negative regulation of CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	22730529	MGI
involved in negative regulation of NK T cell proliferation	IMP IMP: Inferred from mutant phenotype	23105140	MGI
acts upstream of or within negative regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	23034280	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	23034280	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22730529	MGI
involved in positive regulation of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	24880459	MGI
involved in positive regulation of SREBP signaling pathway	IMP IMP: Inferred from mutant phenotype	29420538	MGI
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	28784777	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28784777	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21357543	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24880459	MGI
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	29420538	MGI
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	23105140	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7937772	MGI
acts upstream of or within regulation of CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	18776904	MGI
acts upstream of or within regulation of T-helper cell differentiation	IMP IMP: Inferred from mutant phenotype	18776904	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23034280	MGI
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	29420538	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	29420538	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 7B

T-helper-inducing POZ/Krueppel-like factor	Vzinc finger and BTB domain containing 7B
krueppel-related zinc finger protein cKrox	zinc finger protein 67
zinc finger protein Th-POK

Zbtb7b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Zbtb7b	Q64321	Tmpo	Mus musculus	Q61029	Anti Bait CoIP	22726435

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15980	ZBTB7B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zbtb7b	NCBI	NCBI:51043

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