Pdcd6ip - programmed cell death 6 interacting protein Gene

Mus musculus

Also known as Aip1; Alix; Eig2; mKIAA1375

Gene ID: 18571 | Gene type: protein coding

About Pdcd6ip

Summary

Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of epithelial cell apical/basal polarity. Located in actomyosin; cytosol; and extracellular exosome. Is expressed in hindgut; midgut; rectum; and thymus primordium. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd6ip Products(3)

mRNA	Protein	Name
NM_001164677.1	NP_001158149.1	programmed cell death 6-interacting protein isoform 1
NM_001164678.1	NP_001158150.1	programmed cell death 6-interacting protein isoform 2
NM_011052.2	NP_035182.2	programmed cell death 6-interacting protein isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19523902	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	10200558	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actomyosin contractile ring assembly	IMP IMP: Inferred from mutant phenotype	27336173	MGI
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	27336173	MGI
involved in extracellular exosome biogenesis	IMP IMP: Inferred from mutant phenotype	25686249	MGI
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	25686249	MGI
involved in maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	27336173	MGI
involved in regulation of membrane permeability	IMP IMP: Inferred from mutant phenotype	27336173	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actomyosin	IDA IDA: Inferred from direct assay	27336173	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9880530	MGI
located in extracellular exosome	IDA IDA: Inferred from direct assay	23523921	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

programmed cell death 6-interacting protein

ALG-2-interacting protein 1	ALG-2-interacting protein X
Alg2-interacting protein 1	Alg2-interacting protein X
E2f1-inducible protein

Pdcd6ip Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pdcd6ip	Q9WU78	Sdcbp	Mus musculus	O08992	Y2H	22660413

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10195	PDCD6IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdcd6ip	NCBI	NCBI:10015

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