2. Gene
  3. Rigi - RNA sensor RIG-I Gene

Rigi - RNA sensor RIG-I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ddx58; RIG-I; RLR-1; C330021E21; 6430573D20Rik

Gene ID: 230073 | Gene type: protein coding

About Rigi

Summary

Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Involved in innate immune response; positive regulation of cytokine production; and response to virus. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in several cellular components, including actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; olfactory epithelium; ovary; and renal calyx. Orthologous to human DDX58 (DExD/H-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]

Rigi Products(1)

mRNA Protein Name
NM_172689.3 NP_766277.3 antiviral innate immune response receptor RIG-I
Protein Preferred Names Protein Names

antiviral innate immune response receptor RIG-I

ATP-dependent RNA helicase DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

DEAD box protein 58

DEAD/H box helicase 58

DEAD/H box polypeptide RIG-I

RIG-1

RIG-I-like receptor 1

probable ATP-dependent RNA helicase DDX58

retinoic acid-inducible gene 1

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101954 Inarigivir Inhibitor 99.20% Phase 2
HY-101954A Inarigivir ammonium Inhibitor 99.04% Phase 2
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107202 Polyinosinic-polycytidylic acid Agonist 99.40% Unkown
HY-135748 Polyinosinic-polycytidylic acid sodium 99.40% Unkown
HY-147124 RIG012 Inhibitor ≥99.0% Unkown
HY-107202A Poly (I:C):Kanamycin (1:1) Agonist 51.00% Unkown
HY-P1934 Cyclo(Phe-Pro) Inhibitor 98.77% Unkown
HY-135748A Poly (I:C):Kanamycin (1:1) (sodium) / Unkown
HY-P1934A Cyclo(L-Phe-L-Pro) Inhibitor 99.91% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-134958 Polyinosinic-polycytidylic acid potassium / Unkown
HY-RS11972 RIGI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18258 Rigi Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rigi NCBI NCBI:23586