Mib1 - MIB E3 ubiquitin protein ligase 1 Gene

Mus musculus

Also known as Mib; DIP-1; mindbomb; E430019M12Rik

Gene ID: 225164 | Gene type: protein coding

About Mib1

Summary

Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and positive regulation of endocytosis. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain ventricular layer; cranial ganglion; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mib1 Products(2)

mRNA	Protein	Name
NM_001364997.1	NP_001351926.1	E3 ubiquitin-protein ligase MIB1
NM_144860.3	NP_659109.2	E3 ubiquitin-protein ligase MIB1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16000382	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16000382	MGI
acts upstream of or within positive regulation of endocytosis	IDA IDA: Inferred from direct assay	16000382	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	16000382	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	16000382	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17728463	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17728463	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17728463	MGI
is active in postsynaptic density	EXP EXP: Inferred from Experiment	17728463	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	17728463	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	17728463	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MIB1

DAPK-interacting protein-1	RING-type E3 ubiquitin transferase MIB1
mind bomb homolog 1	mindbomb E3 ubiquitin protein ligase 1
mindbomb homolog 1	skeletrophin

Mib1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mib1	Q80SY4	CMIP	Homo sapiens	Q8IY22	Anti Tag CoIP	20018188
Cross	Mib1	Q80SY4	snx5	Danio rerio	Q803H8	IF	16857196
Cross	Mib1	Q80SY4	snx5	Danio rerio	Q803H8	Anti Tag CoIP	16857196

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08422	MIB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22234	Mib1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mib1	NCBI	NCBI:57534

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