Wrn - Werner syndrome RecQ like helicase Gene

Mus musculus

Gene ID: 22427 | Gene type: protein coding

About Wrn

Summary

Enables 3'-5' exonuclease activity. Involved in G-quadruplex DNA unwinding. Acts upstream of or within several processes, including multicellular organism aging; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Wrn Products(2)

mRNA	Protein	Name
NM_001122822.1	NP_001116294.1	bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
NM_011721.4	NP_035851.3	bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	10871373	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11301316	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA metabolic process	IMP IMP: Inferred from mutant phenotype	11756244	MGI
involved in DNA replication	IGI IGI: Inferred from genetic interaction	26195664	MGI
acts upstream of or within DNA replication	IMP IMP: Inferred from mutant phenotype	9789047	MGI
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	26195664	MGI
involved in G-quadruplex DNA unwinding	IGI IGI: Inferred from genetic interaction	26195664	MGI
involved in G-quadruplex DNA unwinding	IMP IMP: Inferred from mutant phenotype	26195664	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	15235603	MGI
acts upstream of or within regulation of growth rate	IMP IMP: Inferred from mutant phenotype	12707040	MGI
acts upstream of or within replicative senescence	IMP IMP: Inferred from mutant phenotype	10757812	MGI
acts upstream of or within telomere maintenance	IGI IGI: Inferred from genetic interaction	15235603	MGI
acts upstream of or within telomere maintenance	IMP IMP: Inferred from mutant phenotype	12707040	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	26195664	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	11420665	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	11420665	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9789047	MGI
located in replication fork	IMP IMP: Inferred from mutant phenotype	26195664	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Werner syndrome ATP-dependent helicase homolog

Werner syndrome homolog	Werner syndrome protein homolog
exonuclease WRN

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-169422	GSK4418959	Inhibitor	99.07%	Phase 2
HY-148699	HRO761	Inhibitor	99.58%	Phase 1
HY-158116	VVD-214	Inhibitor	99.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12342	ML216	Inhibitor	99.89%	Unkown
HY-110185	NSC 617145	Inhibitor	99.53%	Unkown
HY-149887	H3B-968		98.22%	Unkown
HY-148740	Werner syndrome RecQ helicase-IN-3	Inhibitor	99.94%	Unkown
HY-162471	GSK_WRN3	Inhibitor	98.54%	Unkown
HY-128712	NCGC00029283	Inhibitor	98.88%	Unkown
HY-163942	GSK_WRN4	Inhibitor	98.85%	Unkown
HY-156579	WRN inhibitor 3	Inhibitor	99.54%	Unkown
HY-156580	WRN inhibitor 4	Inhibitor	99.40%	Unkown
HY-156581	WRN inhibitor 5	Inhibitor	98.12%	Unkown
HY-160859	WRN inhibitor 8	Inhibitor	98.07%	Unkown
HY-148741	Werner syndrome RecQ helicase-IN-4	Inhibitor	98.13%	Unkown
HY-153692	WRN inhibitor 1	Inhibitor	98.05%	Unkown
HY-163941	GSK_WRN2		95.95%	Unkown
HY-175750	MOMA-341	Inhibitor	/	Unkown
HY-148700	Werner syndrome RecQ helicase-IN-2	Inhibitor	99.32%	Unkown
HY-153973	WRN inhibitor 2		99.60%	Unkown
HY-169422A	GSK4418959 (enantiomer)		95.0%	Unkown
HY-158025	Anticancer agent 198	Inhibitor	/	Unkown
HY-153692A	(R)-WRN inhibitor 1		/	Unkown
HY-157954	WRN inhibitor 6		/	Unkown
HY-161386	WRN inhibitor 7		/	Unkown
HY-163797	WRN inhibitor 10	Inhibitor	/	Unkown
HY-164852	WRN inhibitor 13		/	Unkown
HY-168583	WRN inhibitor 11	Inhibitor	/	Unkown
HY-168592	WRN inhibitor 12	Inhibitor	/	Unkown
HY-168933	KWR095	Inhibitor	/	Unkown
HY-168934	KWR137	Inhibitor	/	Unkown
HY-169414	WRN inhibitor 15		/	Unkown
HY-169423	WRN inhibitor 17	Inhibitor	/	Unkown
HY-169424	WRN inhibitor 18	Inhibitor	/	Unkown
HY-169928	WRN inhibitor 14	Inhibitor	/	Unkown
HY-174217	WRN-IN-19	Inhibitor	/	Unkown
HY-176727	WRN inhibitor 19	Inhibitor	/	Unkown
HY-178474	WRN inhibitor 20		/	Unkown
HY-178991	WRN-IN-21	Inhibitor	/	Unkown
HY-RS15847	WRN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16538	Wrn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22970	Wrn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wrn	NCBI	NCBI:7486

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