2. Gene
  3. Vip - vasoactive intestinal polypeptide Gene

Vip - vasoactive intestinal polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 22353 | Gene type: protein coding

About Vip

Summary

This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of Insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Vip Products(7)

mRNA Protein Name
NM_001313969.1 NP_001300898.1 VIP peptides isoform 2 preproprotein
NM_001407530.1 NP_001394459.1 VIP peptides isoform 3 preproprotein
NM_001407531.1 NP_001394460.1 VIP peptides isoform 4 preproprotein
NM_001407532.1 NP_001394461.1 VIP peptides isoform 5 preproprotein
NM_001407533.1 NP_001394462.1 VIP peptides isoform 6 preproprotein
NM_001407534.1 NP_001394463.1 VIP peptides isoform 7 preproprotein
NM_011702.3 NP_035832.1 VIP peptides isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables hormone activity IDA
IDA: Inferred from direct assay
9603988 MGI
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9603988 MGI
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
9603988 MGI
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
9603988 MGI
acts upstream of or within regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
21737879 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

VIP peptides

PHI, peptide histidine isoleucine

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0012 Aviptadil Inhibitor 99.87% Unkown
HY-P0012A Aviptadil acetate Inhibitor 99.87% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-103019B (-)-Enitociclib 99.85% Phase 1
HY-103019E Enitociclib / Phase 1
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0221 PACAP (1-38), human, ovine, rat 99.88% Unkown
HY-103019 (+)-Enitociclib 99.89% Unkown
HY-P0220A PACAP (6-38), human, ovine, rat TFA 98.76% Unkown
HY-P5005 VIPhyb 99.73% Unkown
HY-103019A (±)-Enitociclib 99.87% Unkown
HY-P1023 VIP(6-28)(human, rat, porcine, bovine) Antagonist 99.69% Unkown
HY-P4127A M65 TFA Inhibitor / Unkown
HY-P1015 VIP(Guinea pig) Ligand 98.66% Unkown
HY-P1159A [D-p-Cl-Phe6,Leu17]-VIP TFA 98.06% Unkown
HY-P4195A [K15,R16,L27]VIP(1-7)/GRF(8-27) acetate Agonist 98.58% Unkown
HY-P0221C PACAP (1-38) free acid 99.84% Unkown
HY-P4776 Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) Antagonist 98.27% Unkown
HY-P3117 PACAP (6-27) (human, ovine, rat) Antagonist 98.89% Unkown
HY-P0220 PACAP (6-38), human, ovine, rat 99.14% Unkown
HY-P10948A CS-VIP 8 TFA Inhibitor / Unkown
HY-P4195 [K15,R16,L27]VIP(1-7)/GRF(8-27) Agonist / Unkown
HY-172680 DSPE-PEG1000-VIP / Unkown
HY-172681 DSPE-PEG2000-VIP / Unkown
HY-172681A DSPE-PEG3400-VIP / Unkown
HY-172682 DSPE-PEG5000-VIP / Unkown
HY-173339 VIP36 Agonist / Unkown
HY-P0211 [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Antagonist / Unkown
HY-P0221A PACAP (1-38), human, ovine, rat TFA / Unkown
HY-P0221B PACAP (1-38) free acid TFA / Unkown
HY-P1015A VIP(Guinea pig) TFA Ligand / Unkown
HY-P10768 Ro 25-1553 Agonist / Unkown
HY-P10948 CS-VIP 8 Inhibitor / Unkown
HY-P1158 [Ala2,8,9,11,19,22,24,25,27,28]-VIP / Unkown
HY-P1159 [D-p-Cl-Phe6,Leu17]-VIP Antagonist / Unkown
HY-P1767 Prepro VIP (81-122), human / Unkown
HY-P2702 Helodormin Agonist / Unkown
HY-P3050 Helospectin II Inhibitor / Unkown
HY-P3053 Helospectin I / Unkown
HY-RS15653 VIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-164429 VIP236 / Unkown
HY-RS16586 Vip Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23021 Vip Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vip NCBI NCBI:7432