Thra - thyroid hormone receptor alpha Gene

Mus musculus

Also known as Rvr; Erba; Nr1a1; Thra1; Thra2; T3R[a]; T3Ralpha; c-erbA-1; c-erbAalpha; c-erbA-alpha; 6430529J03Rik

Gene ID: 21833 | Gene type: protein coding

About Thra

Summary

The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid Hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Thra Products(2)

mRNA	Protein	Name
NM_001313983.1	NP_001300912.1	thyroid hormone receptor alpha isoform 1
NM_178060.4	NP_835161.1	thyroid hormone receptor alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA binding	IDA IDA: Inferred from direct assay	16322094	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17952069	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	15322135	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11641275	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15340084	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19001373	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	9927422	MGI
acts upstream of or within cartilage condensation	IMP IMP: Inferred from mutant phenotype	9250685	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18203951	MGI
acts upstream of or within female courtship behavior	IMP IMP: Inferred from mutant phenotype	10769387	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	17129617	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8910441	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11641275	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	9250685	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	21652727	MGI
acts upstream of or within positive regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	10769387	MGI
involved in positive regulation of thyroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	8910441	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15340084	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8910441	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19001373	MGI
acts upstream of or within regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	9430637	MGI
acts upstream of or within regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	12869545	MGI
acts upstream of or within regulation of myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18203951	MGI
acts upstream of or within regulation of thyroid hormone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12869545	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	12869545	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	11773436	MGI
acts upstream of or within type I pneumocyte differentiation	IGI IGI: Inferred from genetic interaction	22001906	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	8910441	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17952069	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thyroid hormone receptor alpha

TR alpha 1	TR alpha 2
nuclear receptor subfamily 1 group A member 1

Thra Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Thra	P63058	Cacnb4	Rattus norvegicus	D4A055	Anti Tag CoIP	22892567

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14499	THRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17595	Thra Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24055	Thra Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Thra	NCBI	NCBI:7067
Rattus norvegicus	Thra	NCBI	NCBI:81812

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