Cacnb4 - calcium voltage-gated channel auxiliary subunit beta 4 Gene

Rattus norvegicus

Also known as CAB4

Gene ID: 58942 | Gene type: protein coding

About Cacnb4

Summary

Enables protein kinase binding activity and voltage-gated Calcium Channel activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of protein localization to nucleolus; and positive regulation of voltage-gated Calcium Channel activity. Located in cytoplasm; nuclear speck; and nucleolus. Is active in presynapse. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb4 Products(2)

mRNA	Protein	Name
NM_001105733.2	NP_001099203.1	voltage-dependent L-type calcium channel subunit beta-4 isoform 2
NM_001399143.1	NP_001386072.1	voltage-dependent L-type calcium channel subunit beta-4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11988102	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	18205403	RGD
enables voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	12821675	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transport	IMP IMP: Inferred from mutant phenotype	12821675	RGD
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	28587927	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	28587927	RGD
involved in positive regulation of protein localization to nucleolus	IDA IDA: Inferred from direct assay	28587927	RGD
involved in positive regulation of voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	12821675	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	28587927	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	10931840	RGD
is active in presynapse	IMP IMP: Inferred from mutant phenotype	10931840	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-dependent L-type calcium channel subunit beta-4

calcium channel beta 4 subunit	calcium channel voltage-dependent subunit beta 4
calcium channel, voltage-dependent, beta 4 subunit

Cacnb4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Cacnb4	D4A055	Thra	Mus musculus	P63058	Y2H	22892567
Cross	Cacnb4	D4A055	Ppp2r5d	Mus musculus	Q91V89	Y2H	22892567

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01808	CACNB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cacnb4	NCBI	NCBI:785

Name
Email *

	Sorry, but the email address you supplied was invalid.