Thra - thyroid hormone receptor alpha Gene

Rattus norvegicus

Also known as ERBA1; Thra1; c-erbA-1

Gene ID: 81812 | Gene type: protein coding

About Thra

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; digestive tract development; and regulation of transcription, DNA-templated. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (Thyroid Hormone Receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Thra Products(2)

mRNA	Protein	Name
NM_001017960.2	NP_001017960.1	thyroid hormone receptor alpha isoform TRalpha1
NM_031134.2	NP_112396.2	c-erbAalpha2 isoform TRalpha2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12039959	RGD
enables intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20368265	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20078863	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8407924	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8407924	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8407924	RGD
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	16356627	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	17496154	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	17496154	RGD
involved in embryonic organ development	IEP IEP: Inferred from expression pattern	17496154	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	17496154	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	17496154	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	17496154	RGD
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	2537467	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12039959	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19794517	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18930353	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thyroid hormone receptor alpha

c-erbAalpha2

C-erbA-alpha	avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1
c-erb-A thyroid hormone receptor	c-erbA-alpha2
nuclear receptor subfamily 1 group A member 1	thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14499	THRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17595	Thra Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24055	Thra Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Thra	NCBI	NCBI:7067
Mus musculus	Thra	NCBI	NCBI:21833

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