Git1 - GIT ArfGAP 1 Gene

Mus musculus

Also known as Cat-1; p95Cat

Gene ID: 216963 | Gene type: protein coding

About Git1

Summary

Predicted to enable several functions, including GTPase activator activity; gamma-tubulin binding activity; and small GTPase binding activity. Predicted to be a structural constituent of postsynaptic specialization. Involved in several processes, including cell redox homeostasis; modulation of chemical synaptic transmission; and nervous system development. Acts upstream of or within Ephrin Receptor signaling pathway. Located in calyx of Held and postsynapse. Is expressed in embryo. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]

Git1 Products(2)

mRNA	Protein	Name
NM_001004144.1	NP_001004144.1	ARF GTPase-activating protein GIT1 isoform 1
NM_001374758.1	NP_001361687.1	ARF GTPase-activating protein GIT1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10428811	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17310244	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	25792865	MGI
involved in cell redox homeostasis	IMP IMP: Inferred from mutant phenotype	32460388	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	32460388	MGI
acts upstream of or within ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	17310244	MGI
involved in intramembranous ossification	IMP IMP: Inferred from mutant phenotype	32460388	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	25792865	MGI
involved in motor learning	IMP IMP: Inferred from mutant phenotype	25792865	MGI
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	32460388	MGI
involved in negative regulation of inflammatory response to wounding	IMP IMP: Inferred from mutant phenotype	32460388	MGI
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	32460388	MGI
involved in neuron development	IMP IMP: Inferred from mutant phenotype	25792865	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26637799	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26637799	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	26637799	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	26637799	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	IDA IDA: Inferred from direct assay	26637799	MGI
is active in calyx of Held	IMP IMP: Inferred from mutant phenotype	26637799	MGI
located in postsynapse	IDA IDA: Inferred from direct assay	24297929	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	26637799	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ARF GTPase-activating protein GIT1

ARF GAP GIT1	G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
G protein-coupled receptor kinase-interactor 1	GRK-interacting protein 1

Git1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Git1	Q68FF6	Arhgef7	Mus musculus	Q9ES28	Anti Bait CoIP	16959763
Intra	Git1	Q68FF6	Arhgef7	Mus musculus	Q9ES28	Anti Bait CoIP	19022416

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152095	PPI-GIT1/β-Pix PPI-IN-1	Inhibitor	99.01%	Unkown
HY-RS05438	GIT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19605	Git1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26101	Git1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Git1	NCBI	NCBI:28964

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