Ythdf2 - YTH N6-methyladenosine RNA binding protein 2 Gene

Mus musculus

Also known as HGRG8; NY-REN-2; 9430020E02Rik

Gene ID: 213541 | Gene type: protein coding

About Ythdf2

Summary

Enables N6-methyladenosine-containing RNA binding activity. Involved in several processes, including gamete generation; hematopoietic stem cell proliferation; and negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in brain. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ythdf2 Products(1)

mRNA	Protein	Name
NM_145393.4	NP_663368.3	YTH domain-containing family protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N6-methyladenosine-containing RNA reader activity	IMP IMP: Inferred from mutant phenotype	29855337	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in gamete generation	IMP IMP: Inferred from mutant phenotype	32943573	MGI
involved in hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	30065315	MGI
involved in mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	29855337	MGI
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	29855337	MGI
involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	28867294	MGI
NOT involved in positive regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	32943573	MGI
involved in regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	31959747	MGI
involved in regulation of hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	30065315	MGI
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	32943573	MGI
involved in regulation of meiotic cell cycle process involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	28867294	MGI
involved in regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	29855337	MGI
involved in spermatogonial cell division	IMP IMP: Inferred from mutant phenotype	31959747	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28867294	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	32943573	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

YTH domain-containing family protein 2

YTH domain family 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154919	DC-Y13-27	Inhibitor	99.52%	Unkown
HY-173008	YTHDF2-IN-1	Inhibitor	99.42%	Unkown
HY-168610	YTH-IN-1	Inhibitor	98.66%	Unkown
HY-176848	SKLB-Y13	Inhibitor	/	Unkown
HY-RS15938	YTHDF2 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ythdf2	NCBI	NCBI:51441

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