Stat1 - signal transducer and activator of transcription 1 Gene

Mus musculus

Also known as 2010005J02Rik

Gene ID: 20846 | Gene type: protein coding

About Stat1

Summary

Enables DNA-binding transcription factor activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and defense response to Other organism. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast Cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]

Stat1 Products(4)

mRNA	Protein	Name
NM_001205313.1	NP_001192242.1	signal transducer and activator of transcription 1 isoform 1
NM_001205314.1	NP_001192243.1	signal transducer and activator of transcription 1 isoform 2
NM_001357627.1	NP_001344556.1	signal transducer and activator of transcription 1 isoform 2
NM_009283.4	NP_033309.3	signal transducer and activator of transcription 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	37327784	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	15485925	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11972023	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22306691	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15485925	MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	10692450	MGI
involved in cell population proliferation	IGI IGI: Inferred from genetic interaction	15781341	MGI
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11972023	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	21606371	MGI
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	12872135	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	32270034	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within negative regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	22865856	MGI
acts upstream of or within response to bacterium	IDA IDA: Inferred from direct assay	15661922	MGI
acts upstream of or within response to exogenous dsRNA	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12872135	MGI
involved in response to type I interferon	IDA IDA: Inferred from direct assay	24882218	MGI
involved in response to type II interferon	IDA IDA: Inferred from direct assay	11972023	MGI
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12138178	MGI
involved in type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12138178	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12634107	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12957148	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115594	Erasin	Inhibitor	96.02%	Unkown
HY-149209	LL-K8-22	Inhibitor	99.76%	Unkown
HY-122891	SB02024	Activator	99.70%	Unkown
HY-156466	QL-1200186	Inhibitor	99.95%	Unkown
HY-170621	STAT1/3-IN-1	Inhibitor	/	Unkown
HY-161060	Zharp1-211	Inhibitor	99.15%	Unkown
HY-119956	Biflorin	Inhibitor	99.54%	Unkown
HY-169360	SD-436	Degrader	98.27%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99143	Anti-Mouse NK1.1 Antibody (PK136)	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat1	NCBI	NCBI:6772

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