Srebf1 - sterol regulatory element binding transcription factor 1 Gene

Mus musculus

Also known as ADD1; SREBP1; bHLHd1

Gene ID: 20787 | Gene type: protein coding

About Srebf1

Summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]

Srebf1 Products(4)

mRNA	Protein	Name
NM_001313979.1	NP_001300908.1	sterol regulatory element-binding protein 1 isoform b
NM_001358314.1	NP_001345243.1	sterol regulatory element-binding protein 1 isoform c
NM_001358315.1	NP_001345244.1	sterol regulatory element-binding protein 1 isoform d
NM_011480.4	NP_035610.1	sterol regulatory element-binding protein 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11829742	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8833906	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	21531336	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16443825	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15637161	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14654692	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19244231	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14654692	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	16407292	MGI
acts upstream of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	9329978	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19786558	MGI
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22331133	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	17074803	MGI
acts upstream of insulin secretion	IMP IMP: Inferred from mutant phenotype	16890542	MGI
involved in lipid biosynthetic process	IDA IDA: Inferred from direct assay	21459323	MGI
acts upstream of or within mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22331133	MGI
acts upstream of or within negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	16890542	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17074803	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17636037	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11090130	MGI
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	8833906	MGI
acts upstream of or within positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	9329978	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	21531336	MGI
involved in positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	21531336	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	23823476	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9329978	MGI
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	19244231	MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	16046411	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12242332	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21459323	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	19564420	MGI
acts upstream of or within regulation of heart rate by chemical signal	IMP IMP: Inferred from mutant phenotype	18060044	MGI
acts upstream of or within regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18178930	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8833906	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21531336	MGI
acts upstream of or within response to glucose	IMP IMP: Inferred from mutant phenotype	18178930	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16890542	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16100574	MGI
located in membrane	IDA IDA: Inferred from direct assay	11090130	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11090130	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sterol regulatory element-binding protein 1

adipocyte determination- and differentiation-dependent factor 1

Srebf1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Srebf1	Q9WTN3	Sirt1	Mus musculus	Q923E4	Anti Bait CoIP	20817729

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13757	SREBF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17721	Srebf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24186	Srebf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29460	SREBF1 Pig Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srebf1	NCBI	NCBI:6720

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