Rac1 - Rac family small GTPase 1 Gene

Mus musculus

Also known as D5Ertd559e

Gene ID: 19353 | Gene type: protein coding

About Rac1

Summary

Enables GTP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in several processes, including engulfment of apoptotic cell; nervous system development; and regulation of cell migration. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; cochlea morphogenesis; and neuron differentiation. Located in several cellular components, including kinocilium; pericentriolar material; and ruffle membrane. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rac1 Products(2)

mRNA	Protein	Name
NM_001347530.1	NP_001334459.1	ras-related C3 botulinum toxin substrate 1 isoform 1
NM_009007.2	NP_033033.1	ras-related C3 botulinum toxin substrate 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein activity	IDA IDA: Inferred from direct assay	17058265	MGI
enables GTP binding	IDA IDA: Inferred from direct assay	12783890	MGI
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	10954424	MGI
enables GTPase activity	IDA IDA: Inferred from direct assay	10699171	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8464478	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	21178006	MGI
involved in Rac protein signal transduction	IGI IGI: Inferred from genetic interaction	14622576	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	18953410	MGI
acts upstream of or within actin filament polymerization	IDA IDA: Inferred from direct assay	22750946	MGI
acts upstream of or within anatomical structure arrangement	IMP IMP: Inferred from mutant phenotype	20016102	MGI
acts upstream of or within angiotensin-activated signaling pathway involved in heart process	IDA IDA: Inferred from direct assay	26975711	MGI
acts upstream of or within auditory receptor cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20016102	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	17409253	MGI
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	14657280	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	15728191	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	20016102	MGI
acts upstream of or within cerebral cortex GABAergic interneuron development	IGI IGI: Inferred from genetic interaction	23258346	MGI
acts upstream of or within cerebral cortex radially oriented cell migration	IMP IMP: Inferred from mutant phenotype	17409253	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	20016102	MGI
acts upstream of or within cytoskeleton organization	IDA IDA: Inferred from direct assay	14657280	MGI
acts upstream of or within dendrite development	IDA IDA: Inferred from direct assay	12213441	MGI
acts upstream of or within dendrite morphogenesis	IGI IGI: Inferred from genetic interaction	20335472	MGI
acts upstream of or within dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	18953410	MGI
acts upstream of or within embryonic olfactory bulb interneuron precursor migration	IMP IMP: Inferred from mutant phenotype	17409253	MGI
acts upstream of or within endocytosis	IDA IDA: Inferred from direct assay	12446704	MGI
involved in engulfment of apoptotic cell	IDA IDA: Inferred from direct assay	20691665	MGI
involved in enzyme-linked receptor protein signaling pathway	IGI IGI: Inferred from genetic interaction	14622576	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20016102	MGI
acts upstream of or within erythrocyte enucleation	IMP IMP: Inferred from mutant phenotype	18264091	MGI
involved in forebrain development	IDA IDA: Inferred from direct assay	19007770	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	23258346	MGI
acts upstream of or within hyperosmotic response	IDA IDA: Inferred from direct assay	12783890	MGI
acts upstream of or within interneuron migration	IMP IMP: Inferred from mutant phenotype	17409253	MGI
acts upstream of or within lamellipodium assembly	IDA IDA: Inferred from direct assay	15728191	MGI
involved in midbrain dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	18953410	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	17409253	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	22959435	MGI
involved in neuron projection morphogenesis	IGI IGI: Inferred from genetic interaction	21483795	MGI
involved in non-canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	21483795	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	10934045	MGI
acts upstream of or within positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	12853475	MGI
acts upstream of or within positive regulation of dendritic spine development	IGI IGI: Inferred from genetic interaction	25865668	MGI
acts upstream of or within positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	25865668	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	23412604	MGI
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	19625648	MGI
involved in positive regulation of ovarian follicle development	IMP IMP: Inferred from mutant phenotype	27050391	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15728722	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI IGI: Inferred from genetic interaction	14622576	MGI
acts upstream of or within protein localization to plasma membrane	IDA IDA: Inferred from direct assay	23184663	MGI
acts upstream of or within regulation of ERK5 cascade	IDA IDA: Inferred from direct assay	26975711	MGI
involved in regulation of cell adhesion involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	25514037	MGI
acts upstream of or within regulation of cell morphogenesis	IGI IGI: Inferred from genetic interaction	23258346	MGI
involved in regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	25074804	MGI
acts upstream of or within regulation of neuron maturation	IGI IGI: Inferred from genetic interaction	23258346	MGI
acts upstream of or within regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	17409253	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IGI IGI: Inferred from genetic interaction	25865668	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	25865668	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	31369617	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	31369617	MGI
involved in regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	27050391	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	34269176	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	34269176	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	35263589	MGI
involved in ruffle assembly	IMP IMP: Inferred from mutant phenotype	10934045	MGI
acts upstream of or within small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	12525493	MGI
acts upstream of or within substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	18156211	MGI
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19625648	MGI
acts upstream of or within synaptic transmission, GABAergic	IGI IGI: Inferred from genetic interaction	23258346	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	15728722	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12213441	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12783890	MGI
located in early endosome membrane	IDA IDA: Inferred from direct assay	25074804	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31369617	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31369617	MGI
located in kinocilium	IDA IDA: Inferred from direct assay	23533177	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	12783890	MGI
located in membrane	IDA IDA: Inferred from direct assay	14657280	MGI
located in nucleus	IDA IDA: Inferred from direct assay	25074804	MGI
located in pericentriolar material	IDA IDA: Inferred from direct assay	23533177	MGI
located in phagocytic cup	IDA IDA: Inferred from direct assay	10934045	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14516655	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	34269176	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	34269176	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	10934045	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	34269176	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related C3 botulinum toxin substrate 1

RAS-related C3 botulinum substrate 1

p21-Rac1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112842	MBQ-167	Inhibitor	99.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (65)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18723	Yoda 1		99.98%	Unkown
HY-15723A	NSC 23766 trihydrochloride		99.41%	Unkown
HY-12755	ML141		99.96%	Unkown
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-100047	Nα,Nα-Bis(carboxymethyl)-L-lysine		98.80%	Unkown
HY-124306	ML-099	Activator	99.75%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-125792	Nexinhib20	Inhibitor	99.69%	Unkown
HY-118208	ML-097	Inhibitor	99.90%	Unkown
HY-110100	CPYPP	Inhibitor	99.94%	Unkown
HY-U00145	Digeranyl bisphosphonate	Inhibitor	99.07%	Unkown
HY-N0710	alpha-Cyperone		99.68%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-136383	AZA1		98.07%	Unkown
HY-113849	MLS-573151	Inhibitor	99.70%	Unkown
HY-102078	ZINC69391		99.76%	Unkown
HY-B0580B	(R)-Ketorolac	Inhibitor	99.65%	Unkown
HY-119576	Phox-I2	Inhibitor	99.52%	Unkown
HY-120213	YH-306		98.34%	Unkown
HY-112307A	(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium		99.97%	Unkown
HY-133146	DJ001	Inhibitor	99.68%	Unkown
HY-158304	Rac1-IN-4	Inhibitor	98.61%	Unkown
HY-107501	(Rac)-1-Oleoyl lysophosphatidic acid sodium	Control	≥98.0%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-156668	Rac1-IN-3	Inhibitor	98.28%	Unkown
HY-P1382A	Rac1 Inhibitor W56 TFA	Inhibitor	99.92%	Unkown
HY-RS11591	RAC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-152095	PPI-GIT1/β-Pix interaction-IN-1	Inhibitor	99.01%	Unkown
HY-W013060	(Rac)-1,2-Dilinoleoyl-3-palmitoyl-glycerol		/	Unkown
HY-W127550	1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium		/	Unkown
HY-12646A	Rhosin		95.08%	Unkown
HY-109541S6	(Rac)-Colfosceril miristate-d72		/	Unkown
HY-120229	GGTI-2147	Inhibitor	/	Unkown
HY-131598C	6-Thio-GTP tetrasodium	Inhibitor	/	Unkown
HY-137862A	(Rac)-1-Oleoyl lysophosphatidic acid	Control	/	Unkown
HY-143699S	(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5		/	Unkown
HY-147076	20:4 PG sodium		/	Unkown
HY-167569	(Rac)-1-Palmitoyl-glycero-3-phosphocholine		/	Unkown
HY-170458	18:0-18:2 PG sodium		/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-50733A	CX-5011		/	Unkown
HY-P10038	mP6	Inhibitor	/	Unkown
HY-P10107	TAT-PAK18 R192A	Control	/	Unkown
HY-P1382	Rac1 Inhibitor W56	Inhibitor	/	Unkown
HY-P1383A	Rac1 Inhibitor F56, control peptide TFA	Inhibitor	/	Unkown
HY-W127356	(Rac)-1,2-Distearoyl-3-chloropropanediol-d5		/	Unkown
HY-W127363	(Rac)-1,2-Dihexadecylglycerol		/	Unkown
HY-W127391	1,2-Dilaurin		≥98.0%	Unkown
HY-W127415	rac-1-Stearoyl-3-chloropropanediol		/	Unkown
HY-W127570	rac-1,2-Distearoyl-3-chloropropanediol		/	Unkown
HY-W587715S	(Rac)-1,2-Dioleoyl-3-chloropropanediol-d5		/	Unkown
HY-W777103	(Rac)-1-Oleoyl-3-linoleoyl-glycerol		/	Unkown
HY-W777682	(Rac)-1-Linoleoyl-2,3-isopropylidene-glycerol		/	Unkown
HY-134243	6-T-GDP	Inhibitor	/	Unkown
HY-50733	CX-5011 free base		/	Unkown
HY-RS16742	Rac1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23179	Rac1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W702728	rac 1-Palmitoyl-2-chloropropanediol		/	Unkown
HY-W749756	rac-1,2-Distearoyl-3-chloropropanediol-13C3		/	Unkown
HY-W766801	rac-1-Linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W766807	rac-1,2-Dilinoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W766831	rac 1-oleoyl-2-linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W777866	(Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rac1	NCBI	NCBI:5879

Name
Email *

	Sorry, but the email address you supplied was invalid.