Mbd3 - methyl-CpG binding domain protein 3 Gene

Mus musculus

Gene ID: 17192 | Gene type: protein coding

About Mbd3

Summary

This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of Leukemia Inhibitory Factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Mbd3 Products(2)

mRNA	Protein	Name
NM_001306143.1	NP_001293072.1	methyl-CpG-binding domain protein 3 isoform 2
NM_013595.3	NP_038623.1	methyl-CpG-binding domain protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9774669	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16462733	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17287250	MGI
acts upstream of or within tissue development	IMP IMP: Inferred from mutant phenotype	17287250	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuRD complex	IPI IPI: Inferred from physical interaction	16462733	MGI
located in chromatin	IDA IDA: Inferred from direct assay	9774669	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17546630	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	14643676	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	17546630	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9774669	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	19796622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

methyl-CpG-binding domain protein 3

methyl-CpG-binding protein MBD3

Mbd3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mbd3	Q9Z2D8	Mecom	Mus musculus	P14404	TAP	18500823
Intra	Mbd3	Q9Z2D8	Mecom	Mus musculus	P14404	Anti Bait CoIP	18500823
Intra	Mbd3	Q9Z2D8	Mecom	Mus musculus	P14404	GMS	18500823
Intra	Mbd3	Q9Z2D8	Mecom	Mus musculus	P14404	Confocal	18500823

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08183	MBD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19351	Mbd3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25842	Mbd3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99506	Tamrintamab		98.51%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mbd3	NCBI	NCBI:53615

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