Asic3 - acid-sensing (proton-gated) ion channel 3 Gene

Mus musculus

Also known as Accn3; TNAC1; DRASIC; SLNAC1

Gene ID: 171209 | Gene type: protein coding

About Asic3

Summary

Enables cation channel activity and enterobactin transmembrane transporter activity. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to acidic pH; and response to heat. Is integral component of plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and pectoral girdle and thoracic body wall muscle. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Asic3 Products(2)

mRNA	Protein	Name
NM_001310474.1	NP_001297403.1	acid-sensing ion channel 3 isoform 2
NM_183000.2	NP_892045.2	acid-sensing ion channel 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enterobactin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	19590043	MGI
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11854527	MGI
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	11854527	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within detection of chemical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	12060708	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	19590043	MGI
acts upstream of or within monoatomic cation transport	IDA IDA: Inferred from direct assay	11854527	MGI
acts upstream of or within monoatomic cation transport	IMP IMP: Inferred from mutant phenotype	11854527	MGI
acts upstream of or within monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19590043	MGI
acts upstream of or within response to acidic pH	IDA IDA: Inferred from direct assay	11854527	MGI
acts upstream of or within response to acidic pH	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within response to heat	IMP IMP: Inferred from mutant phenotype	11754838	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	11754838	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11854527	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acid-sensing ion channel 3

amiloride-sensitive cation channel 3

dorsal root ASIC

Related Agents

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107757	GMQ hydrochloride	Activator	99.86%	Unkown
HY-122135	A-317567	Inhibitor	98.45%	Unkown
HY-131879	NS383		99.83%	Unkown
HY-D2868	DAPI	Inhibitor	98.01%	Unkown
HY-P1346A	APETx2 TFA	Inhibitor	98.54%	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	Unkown
HY-P1346	APETx2	Inhibitor	/	Unkown
HY-100939	4-Chlorophenylguanidine hydrochloride	Agonist	99.07%	Unkown
HY-155017	6-Iodoamiloride	Inhibitor	/	Unkown
HY-P1249	Neuropeptide SF(mouse,rat)	Agonist	/	Unkown
HY-P1249A	Neuropeptide SF(mouse,rat) TFA	Agonist	/	Unkown
HY-RS01091	ASIC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17225	Asic3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23678	Asic3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asic3	NCBI	NCBI:9311

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