2. Gene
  3. Hap1 - huntingtin-associated protein 1 Gene

Hap1 - huntingtin-associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HAP-1

Gene ID: 15114 | Gene type: protein coding

About Hap1

Summary

The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein Huntingtin. The protein also interacts with Kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Hap1 Products(3)

mRNA Protein Name
NM_001359052.1 NP_001345981.1 huntingtin-associated protein 1 isoform C
NM_010404.3 NP_034534.1 huntingtin-associated protein 1 isoform A
NM_177981.2 NP_817090.1 huntingtin-associated protein 1 isoform B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9599014 MGI
Biological Process GO Annotation Evidence Reference Source
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
24355921 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
18636121 MGI
involved in hypothalamus cell differentiation IMP
IMP: Inferred from mutant phenotype
24355921 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
18636121 MGI
involved in neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24355921 MGI
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
15379999 MGI
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
24355921 MGI
acts upstream of or within positive regulation of non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21985783 MGI
involved in positive regulation of non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21985783 MGI
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
24366265 MGI
involved in regulation of organelle transport along microtubule IMP
IMP: Inferred from mutant phenotype
24453320 MGI
acts upstream of or within vesicle transport along microtubule IMP
IMP: Inferred from mutant phenotype
15242649 MGI
Cellular Component GO Annotation Evidence Reference Source
located in autophagosome IDA
IDA: Inferred from direct assay
24453320 MGI
located in centriole IDA
IDA: Inferred from direct assay
21985783 MGI
located in centrosome IDA
IDA: Inferred from direct assay
21985783 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15242649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

huntingtin-associated protein 1

Hap1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Hap1 O35668 Ahi1 Mus musculus Q8K3E5
Anti Bait CoIP
21146532
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150221 DB008 Inhibitor 98.78% Unkown
HY-153119 TMX-4153 Degrader 98.96% Unkown
HY-RS00815 APEX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173281 MAT2A-IN-24 Inhibitor / Unkown
HY-174296 TMX-4102 / Unkown
HY-174866 BT-O2C Inhibitor / Unkown
HY-P4096 HAP-1 99.08% Unkown
HY-RS06000 HAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17886 Hap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21480 Apex1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24355 Hap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hap1 NCBI NCBI:9001