C18orf25 - chromosome 18 open reading frame 25 Gene

Homo sapiens

Also known as ARKL1; Ark2N; RNF111L1

Gene ID: 147339 | Gene type: protein coding

About C18orf25

This gene has 6 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 12.5), bone marrow (RPKM 9.9) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Apr 2022]

C18orf25 Products(2)

mRNA	Protein	Name
NM_001008239.3	NP_001008240.1	uncharacterized protein C18orf25 isoform b
NM_145055.5	NP_659492.1	uncharacterized protein C18orf25 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	31341047	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of viral life cycle	IDA IDA: Inferred from direct assay	31341047	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	31341047	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C18orf25 Protein Structure

RNF111_N

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

uncharacterized protein C18orf25

ARKadia-like 1

C18orf25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARK2N	Q96B23	SUMO1P1	Homo sapiens	G2XKQ0	Validated Y2H	25416956
Intra	ARK2N	Q96B23	SUMO1P1	Homo sapiens	G2XKQ0	Y2H Prey Pooling	25416956
Intra	ARK2N	Q96B23	SUMO1P1	Homo sapiens	G2XKQ0	Y2H Array	25416956
Intra	ARK2N	Q96B23	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	ARK2N	Q96B23	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	ARK2N	Q96B23	JAKMIP1	Homo sapiens	Q96N16	Validated Y2H	32296183
Intra	ARK2N	Q96B23	JAKMIP1	Homo sapiens	Q96N16	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	JAKMIP1	Homo sapiens	Q96N16	Y2H Array	32296183
Intra	ARK2N	Q96B23	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	ARK2N	Q96B23	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	ARK2N	Q96B23	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	ARK2N	Q96B23	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	ARK2N	Q96B23	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	ARK2N	Q96B23	SUMO1	Homo sapiens	P63165	Validated Y2H	25416956
Intra	ARK2N	Q96B23	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
Intra	ARK2N	Q96B23	SUMO1	Homo sapiens	P63165	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 18q Deletion Syndrome

18q- Syndrome	Monosomy 18q
Deletion Of Long Arm Of Chromosome 18	Chromosome 18q- Syndrome
Deletion 18q	18q Deletion Syndrome
Distal 18q Deletion Syndrome	Chromosome 18 Long Arm Deletion Syndrome
Chromosome 18q Monosomy	Del Syndrome
Chromosome 18 Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01702	C18orf25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	C18orf25	VGNC	VGNC:70416
Canis familiaris	C18orf25	VGNC	VGNC:52583
Mus musculus	C18orf25	MGD	MGI:2444951
Bos taurus	C18orf25	VGNC	VGNC:106663
Rattus norvegicus	C18orf25	RGD	RGD:1308601
Felis catus	C18orf25	VGNC	VGNC:60621

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