2. Gene
  3. Foxm1 - forkhead box M1 Gene

Foxm1 - forkhead box M1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as WIN; Mpm2; Fkh16; Foxm1b; HFH-11B; MPHOSPH2

Gene ID: 14235 | Gene type: protein coding

About Foxm1

Summary

Enables transcription cis-regulatory region binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of double-strand break repair; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including liver development; positive regulation of transcription by RNA polymerase II; and vasculogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study hepatocellular carcinoma; lung cancer; and type 2 diabetes mellitus. Orthologous to human FOXM1 (forkhead box M1). [provided by Alliance of Genome Resources, Apr 2022]

Foxm1 Products(1)

mRNA Protein Name
NM_008021.4 NP_032047.4 forkhead box protein M1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10523841 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
17261592 MGI
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: Inferred from mutant phenotype
17101782 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15817462 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
15531365 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17101782 MGI
involved in positive regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
17101782 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
15817462 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15817462 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15531365 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
15817462 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
15817462 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
17261592 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein M1

forkhead homolog 16

trident

winged-helix transcription factor Trident

Related Agents

Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0990 Thiostrepton Inhibitor 99.80% Unkown
HY-112721 FDI-6 Inhibitor 99.65% Unkown
HY-19979 RCM-1 Inhibitor 98.56% Unkown
HY-148530 YX-2-107 Degrader 99.22% Unkown
HY-153916 TCRS-417 99.13% Unkown
HY-117522 Sepin-1 Inhibitor 97.89% Unkown
HY-158420 STL001 Inducer 96.25% Unkown
HY-151986 FOXM1-IN-1 Inhibitor 99.54% Unkown
HY-P1687 Siomycin A / Unkown
HY-170944 BAG3/HSP70-IN-1 / Unkown
HY-112509 STL427944 Inhibitor / Unkown
HY-149145 Ena15 / Unkown
HY-156609 FOXM1-IN-2 Inhibitor / Unkown
HY-161617 LASSBio-2052 / Unkown
HY-170552 KC12 Inhibitor / Unkown
HY-P10553 ARF(26–44), cell-permeable / Unkown
HY-RS05064 FOXM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16641 Foxm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23075 Foxm1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxm1 NCBI NCBI:2305